Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial
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Hepatic late adverse effects after antineoplastic treatment for childhood cancerAcute lymphoblastic leukaemiaMercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fictionA genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicityEffect of guanidine hydrochloride and urea on the interaction of 6-thioguanine with human serum albumin: a spectroscopic and molecular dynamics based study.Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial.Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites.A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.Central nervous system disease in hematologic malignancies: historical perspective and practical applications.Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001.Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment responseSynthesis, characterization and cytotoxic studies of water soluble [(η-C(5)H(5))(2)Mo(thionucleobase/thionucleoside)]Cl complexes in breast and colon cancer cell lines.Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia.Prediction of outcome by early bone marrow response in childhood acute lymphoblastic leukemia treated in the ALL-BFM 95 trial: differential effects in precursor B-cell and T-cell leukemiaClinical trials in paediatric haematology-oncology: are future successes threatened by the EU directive on the conduct of clinical trials?Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003.Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics.What can we learn from geographical comparisons of childhood cancer survival?Clofarabine for the treatment of acute lymphoblastic leukemia.Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection.A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginaseHepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature.Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.L-Asparaginase as potent anti-leukemic agent and its significance of having reduced glutaminase side activity for better treatment of acute lymphoblastic leukaemia.Antileukemic drug effects in childhood acute lymphoblastic leukemia.A practical guide to the use of thiopurines in oral medicine.Excellent outcome of minimal residual disease-defined low-risk patients is sustained with more than 10 years follow-up: results of UK paediatric acute lymphoblastic leukaemia trials 1997-2003.IMP dehydrogenase basal activity in MOLT-4 human leukaemia cells is altered by mycophenolic acid and 6-thioguanosine.Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990-2011.Pro-inflammatory and pro-coagulant properties of 6-thioguanine and 6-mercaptopurine: implications for their potential role in the development of sinusoidal obstruction syndrome.Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes.Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups.Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study.Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens.
P2860
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P2860
Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial
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2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@ast
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@en
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial.
@nl
type
label
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@ast
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@en
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial.
@nl
altLabel
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial.
@en
prefLabel
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@ast
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@en
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial.
@nl
P2093
P1433
P1476
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial
@en
Toxicity and efficacy of 6-thi ...... leukaemia: a randomised trial.
@en
P2093
Chris D Mitchell
John Lilleyman
Lynne Lennard
Medical Research Council
National Cancer Research Network Childhood Leukaemia Working Party
Sally E Kinsey
Sue M Richards
T O B Eden
P304
P356
10.1016/S0140-6736(06)69558-5
P407
P577
2006-10-01T00:00:00Z