The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia - Wikidata - awgldk - TriplyDB

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

http://www.wikidata.org/entity/Q29547174

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alpha-Synuclein and neuronal cell death Sulforaphane as a potential protective phytochemical against neurodegenerative diseases Conformational equilibria in monomeric alpha-synuclein at the single-molecule level Structures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein protein Parkinson's disease: from monogenic forms to genetic susceptibility factors Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity Synaptic vesicle trafficking and Parkinson's disease FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients Evidence that alpha-synuclein does not inhibit phospholipase D c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain Interactions between fatty acids and alpha-synuclein Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease Altered ribostasis: RNA-protein granules in degenerative disorders Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.Secondary structure and dynamics of micelle bound beta- and gamma-synuclein Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases Residual structure, backbone dynamics, and interactions within the synuclein family Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models Beta-synuclein gene alterations in dementia with Lewy bodies.Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition Definition of a molecular pathway mediating α-synuclein neurotoxicity α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions Untangling the Manganese-α-Synuclein Web Versatile Structures of α-Synuclein Genetic Profile, Environmental Exposure, and Their Interaction in Parkinson's Disease

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

http://www.wikidata.org/entity/Q29547174

description

2004 nî lūn-bûn

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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

@ast

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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type

label

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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prefLabel

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

@ast

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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P1433

Annals of Neurology

P1476

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

@en

P2093

Begoña Atarés

http://www.w3.org/2001/XMLSchema#string

Elena Lezcano

http://www.w3.org/2001/XMLSchema#string

Estrella Gomez Tortosa

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Israel Ampuero

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Javier Alegre

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Juan C Gómez-Esteban

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Juan J Zarranz

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Justo G de Yebenes

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Lídice Vidal

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Olga Rodriguez

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164-173

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scholarly article

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510461

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10.1002/ANA.10795

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2

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55

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Teodoro Del Ser

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2004-02-01T00:00:00Z

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8891811

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14755719

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P921

Parkinson's disease