Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease - Wikidata - awgldk - TriplyDB

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

http://www.wikidata.org/entity/Q29547175

about

alpha-Synuclein and neuronal cell death Proteome analysis of human substantia nigra in Parkinson's disease Sulforaphane as a potential protective phytochemical against neurodegenerative diseases Conformational equilibria in monomeric alpha-synuclein at the single-molecule level Structures of the E46K mutant-type α-synuclein protein and impact of E46K mutation on the structures of the wild-type α-synuclein protein Parkinson's disease: from monogenic forms to genetic susceptibility factors The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death Dequalinium-induced protofibril formation of alpha-synuclein Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity Synaptic vesicle trafficking and Parkinson's disease Parkin accumulation in aggresomes due to proteasome impairment Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients Evidence that alpha-synuclein does not inhibit phospholipase D c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies Chromosome 6-linked autosomal recessive early-onset Parkinsonism: linkage in European and Algerian families, extension of the clinical spectrum, and evidence of a small homozygous deletion in one family. The French Parkinson's Disease Genetics Study The synucleins Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies Genetics of Parkinson disease Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Secondary structure and dynamics of micelle bound beta- and gamma-synuclein Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies Residual structure, backbone dynamics, and interactions within the synuclein family NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1 Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

P2860

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P2860

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

http://www.wikidata.org/entity/Q29547175

description

1998 nî lūn-bûn

@nan

1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@ast

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@en

type

label

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@ast

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@en

altLabel

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

@en

prefLabel

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@ast

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@en

P1433

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P1476

Q29547175-33F8FA06-C239-4F3B-83A9-585924A4555A

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Q29547175-E1768282-D5B3-4ABB-97E0-DE0001EDBE04

P2860

Q29547175-2A0F1E69-0883-4853-A09A-D610672A3CD2

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Q29547175-F2559C91-A469-49F5-9D7A-4C704B9642DD

P3181

P356

P1433

Nature Genetics

P1476

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

@en

P2093

Epplen JT

http://www.w3.org/2001/XMLSchema#string

Graeber M

http://www.w3.org/2001/XMLSchema#string

Krüger R

http://www.w3.org/2001/XMLSchema#string

Kuhn W

http://www.w3.org/2001/XMLSchema#string

Kösel S

http://www.w3.org/2001/XMLSchema#string

Müller T

http://www.w3.org/2001/XMLSchema#string

Przuntek H

http://www.w3.org/2001/XMLSchema#string

Riess O

http://www.w3.org/2001/XMLSchema#string

Schöls L

http://www.w3.org/2001/XMLSchema#string

Woitalla D

http://www.w3.org/2001/XMLSchema#string

P2860

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

P2888

P304

106-8

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scholarly article

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510459

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P356

10.1038/NG0298-106

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P433

2

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P478

18

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1998-02-01T00:00:00Z

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1011429868

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P698

9462735

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P921

Parkinson's disease