Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
about
MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitusActive-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signalingPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Signaling by target of rapamycin proteins in cell growth controlNutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationThe TOR pathway comes of ageS6K1 plays a critical role in early adipocyte differentiationMammalian target of rapamycin: a central node of complex signaling cascadesProtein kinases and phosphatases in the control of cell fatemTOR is a key modulator of ageing and age-related diseaseMyopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial functionThe Lin28/let-7 axis regulates glucose metabolismThe mTOR signalling pathway in human cancerThe tuberous sclerosis complexMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyMolecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunctionEndoplasmic reticulum stress and the inflammatory basis of metabolic diseasemTOR: from growth signal integration to cancer, diabetes and ageingmTOR signaling in growth control and diseaseRapamycin and mTOR kinase inhibitorsCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1The TSC1-TSC2 complex: a molecular switchboard controlling cell growthAtf4 regulates obesity, glucose homeostasis, and energy expenditureTurnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisIdentification of Sin1 as an essential TORC2 component required for complex formation and kinase activityThe role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistanceFinding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesUsing Drosophila to discover mechanisms underlying type 2 diabetesResveratrol Inhibition of Cellular Respiration: New Paradigm for an Old MechanismBiochemical Genetic Pathways that Modulate Aging in Multiple SpeciesInsulin receptor signaling in normal and insulin-resistant statesNutritional modulation of insulin resistanceReviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose HomeostasisA possible link between BDNF and mTOR in control of food intakeLeucine and mTORC1: a complex relationshipAmino acids and mTORC1: from lysosomes to diseaseAging signaling pathways and circadian clock-dependent metabolic derangements
P2860
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P2860
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@ast
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@en
type
label
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@ast
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@en
prefLabel
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@ast
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@en
P2093
P2860
P3181
P356
P1433
P1476
Absence of S6K1 protects again ...... enhancing insulin sensitivity
@en
P2093
Francesca Frigerio
Frédéric Picard
Johan Auwerx
Melanie Sticker
Mitsuhiro Watanabe
Peter R Allegrini
Sara C Kozma
Stefano Fumagalli
Sung Hee Um
P2860
P2888
P304
P3181
P356
10.1038/NATURE02866
P407
P577
2004-08-11T00:00:00Z
P6179
1042394920