Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
about
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumorsEB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologueThe APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phaseGSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinDifferential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobinAdenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasmThe cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathwayThe human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascadeIdentification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEFFascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cellsWNT7a induces E-cadherin in lung cancer cellsHDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencingNuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferationFGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and developmentA novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signalsInteraction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-cateninSignal transduction by the Wnt family of ligandsAttenuated APC alleles produce functional protein from internal translation initiation.Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosomeInteraction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin releaseEngrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathwayInhibition of Tcf3 binding by I-mfa domain proteinsStructural basis of the Axin-adenomatous polyposis coli interactionInhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting proteinWISP-1 is a Wnt-1- and beta-catenin-responsive oncogeneProtein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cellsHigh-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older menWnt signaling: the good and the badThe estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctionsDomains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localizationDifferential nuclear translocation and transactivation potential of beta-catenin and plakoglobinSelective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesionMicrotubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggsLoss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colonSporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin geneWnt signaling in breast cancer: have we come full circle?The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathwayA simple method for statistical analysis of intensity differences in microarray-derived gene expression data
P2860
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P2860
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@ast
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@en
type
label
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@ast
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@en
prefLabel
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@ast
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@en
P2093
P2860
P3181
P356
P1476
Regulation of intracellular be ...... (APC) tumor-suppressor protein
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.92.7.3046
P407
P577
1995-03-28T00:00:00Z