Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
about
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation studyLow carbohydrate versus isoenergetic balanced diets for reducing weight and cardiovascular risk: a systematic review and meta-analysisA locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivoFine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritabilityPCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular diseaseManaging risks in drug discovery: reproducibility of published findingsAnnexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradationMechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pHSelf-association of human PCSK9 correlates with its LDLR-degrading activitySecreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceRegulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levelsCommon variants at 30 loci contribute to polygenic dyslipidemiaDeep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel diseaseThe PCSK9 decadeA map of human genome variation from population-scale sequencingSix new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humansGenome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry studyTherapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primatesA common allele on chromosome 9 associated with coronary heart diseasePolymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health StudyIntegrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease riskGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChipInhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levelsRecent advances in pathogenesis, assessment, and treatment of atherosclerosisFrom proprotein convertase subtilisin/kexin type 9 to its inhibition: state-of-the-art and clinical implicationsUnmet Needs in LDL-C Lowering: When Statins Won't Do!PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumabThe impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular diseaseClinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reductionGenetics of coronary artery disease and myocardial infarctionApplication of computational methods in genetic study of inflammatory bowel diseaseNew developments in atherosclerosis: clinical potential of PCSK9 inhibitionHypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9Insights into blood lipids from rare variant discoveryCardiovascular pharmacogenomics: current status and future directionsFamilial hypercholesterolemia: present and future managementBenefits & risks of statin therapy for primary prevention of cardiovascular disease in Asian Indians - a population with the highest risk of premature coronary artery disease & diabetesNew therapeutic principles in dyslipidaemia: focus on LDL and Lp(a) lowering drugs
P2860
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P2860
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@ast
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@en
type
label
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@ast
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@en
prefLabel
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@ast
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@en
P2093
P3181
P356
P1476
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
@en
P2093
Boerwinkle E
Mosley TH Jr
P304
P3181
P356
10.1056/NEJMOA054013
P407
P577
2006-03-23T00:00:00Z