Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha - Wikidata - awgldk - TriplyDB

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

http://www.wikidata.org/entity/Q29619709

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Cancer genome landscapes Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells Cancer-associated IDH1 mutations produce 2-hydroxyglutarate IDH1 and IDH2 mutations in gliomas The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Regulation of human metabolism by hypoxia-inducible factor Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas Hypoxia-inducible factors and the response to hypoxic stress Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Recent advances in the molecular understanding of glioblastoma Recurring mutations found by sequencing an acute myeloid leukemia genome HIF-1: upstream and downstream of cancer metabolism Targeting Cancer Metabolism - Revisiting the Warburg Effects Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Mitochondrial metabolic remodeling in response to genetic and environmental perturbations Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment Hypoxia signaling pathways: modulators of oxygen-related organelles Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date From systems to structure: bridging networks and mechanism Reactive oxygen species in cancer stem cells New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma Isocitrate dehydrogenase mutations: new opportunities for translational research Molecular biology of gliomas: present and future challenges Novel delivery strategies for glioblastoma Cancer cell metabolism: implications for therapeutic targets Nutrient sensing, metabolism, and cell growth control Contemporary murine models in preclinical astrocytoma drug development Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1 Glioblastoma genetics: in rapid flux.IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma.

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P2860

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

http://www.wikidata.org/entity/Q29619709

description

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Science

@fr

artículu científicu espublizáu en 2009

@ast

im April 2009 veröffentlichter wissenschaftlicher Artikel

@de

scientific article (publication date: 10 April 2009)

@en

wetenschappelijk artikel (gepubliceerd op 2009/04/10)

@nl

наукова стаття, опублікована у квітні 2009

@uk

مقالة علمية (نشرت في 10-4-2009)

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name

Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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type

label

Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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prefLabel

Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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Glioma-derived mutations in ID ...... activity and induce HIF-1alpha

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Jianping Ding

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Kun-Liang Guan

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Lingling Gong

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Pu Wang

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Shimin Zhao

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Wei Xu

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Wei Yu

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Wenqing Jiang

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Yan Lin

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Yingjie Peng

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P2860

An integrated genomic analysis of human glioblastoma multiforme

IDH1 and IDH2 mutations in gliomas

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

Evaluation of HIF-1 inhibitors as anticancer agents

Malignant astrocytic glioma: genetics, biology, and paths to treatment

Analysis of the IDH1 codon 132 mutation in brain tumors.

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.

Cellular concentrations of enzymes and their substrates.

Mechanism of the inhibitory effect of glyoxylate plus oxaloacetate and oxalomalate on the NADP-specific isocitrate dehydrogenase.

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