Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
about
Molecular targets for flavivirus drug discoveryStructure and functionality in flavivirus NS-proteins: perspectives for drug designEcuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus FlavivirusThe dengue virusesDengue viruses - an overviewThe serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acidsDual mechanisms of pestiviral superinfection exclusion at entry and RNA replication.Mutagenesis of the NS3 protease of dengue virus type 2.Bovine viral diarrhea virus strain Oregon: a novel mechanism for processing of NS2-3 based on point mutationsInsertion of a sequence encoding light chain 3 of microtubule-associated proteins 1A and 1B in a pestivirus genome: connection with virus cytopathogenicity and induction of lethal disease in cattle.Purification and Characterization of West Nile Virus Nucleoside Triphosphatase (NTPase)/Helicase: Evidence for Dissociation of the NTPase and Helicase Activities of the EnzymeMutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in mice.Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient miceLangat Flavivirus Protease NS3 Binds Caspase-8 and Induces ApoptosisThe NS5A Protein of Bovine Viral Diarrhea Virus Contains an Essential Zinc-Binding Site Similar to That of the Hepatitis C Virus NS5A ProteinSubstrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinaseMutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replicationPestivirus NS3 (p80) protein possesses RNA helicase activityAn amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4AFormation of the flavivirus envelope: role of the viral NS2B-NS3 proteaseNS3-4A of hepatitis C virus is a chymotrypsin-like proteaseHepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cellsIdentification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 proteaseThe helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzymeUpregulation of signalase processing and induction of prM-E secretion by the flavivirus NS2B-NS3 protease: roles of protease componentsBovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replicationSerine protease of pestiviruses: determination of cleavage sitesFunctional Analysis of Potential Carboxy-Terminal Cleavage Sites of Tick-Borne Encephalitis Virus Capsid ProteinSignificance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibodyBoth NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteinsProcessing of the intracellular form of the west Nile virus capsid protein by the viral NS2B-NS3 protease: an in vitro studyCharacterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sitesNonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctionsTwo distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virusHepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymesMutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replicationDeletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity
P2860
Q21999123-D39C92BC-60DC-4805-B962-293C8D671D1CQ23011530-AC4204FE-8C93-4C70-A24C-B5BA6B3F61F7Q24289057-AD716918-D8E7-46F3-A93E-BCC56DCA51F5Q24616798-0F15D679-F48B-4A10-9A86-F26D0A352911Q27026302-6E49F925-743E-48B6-9320-5BE0911DF4DCQ27469354-ED890095-381D-4CE5-86E8-15E457564FAFQ27469450-5501C6A8-E442-4AB8-8DFF-4EBAE7873E05Q27469518-63626DDE-DAAC-4C19-866E-B1D1AD667E65Q27469546-BA185877-7FC4-40EA-9A9C-1B249DD6B041Q27469548-CFBAA762-BE07-4E87-9F94-AA6676DF421FQ27469780-104E7F6F-CC89-4DB8-AE19-E6A1A81A7126Q27469868-141C5B27-4273-4F78-ACB8-DA3A02E69A27Q27469872-39CADB5B-7750-4FE4-8255-966B1E7E3A55Q27472688-515BF32B-1AE3-4F36-B984-9671192EAECDQ27472824-3B072CE7-7207-4E1B-A6AE-3F87BA48E0B3Q27472960-F6BAD70E-5781-43BD-BA81-701859527BAAQ27477462-4531DB89-2F24-4070-9029-03536249E5BCQ27478443-8B592684-2724-4655-BAEF-FA9479944474Q27478456-9CD878CC-7A99-44CC-A75C-6715360BC536Q27478458-76FC4E45-4FCF-44B8-A42F-C47D541A64FEQ27478459-02C4CC80-1246-439D-81A6-E45F0E67383EQ27478465-ED4CE5FE-9A03-4E64-8A3B-B8BD29A41A9CQ27478468-EED84A14-82E0-4408-B31E-DF78B41B2AEDQ27478479-BE5ED25E-9D93-41E9-8879-34973E62146CQ27480323-E60C7A63-2CFD-40B0-BAD1-DC9D90F15E0FQ27480758-1F19B345-DF4D-43E4-9493-5AB2B1DD4EBDQ27480807-5576C377-D913-439B-82C5-70723A0B99F9Q27480827-979C3A16-316C-49B2-B7FB-B0728E97533EQ27480836-26B40E83-E6F6-400F-87A7-ECF75A83DF95Q27480838-CD9F9C4D-7735-49DC-9F7F-1032DA3C1F8DQ27485445-C9C9F82C-41B2-4430-8944-D5BA00069468Q27485923-58D89F99-FF73-4855-A691-6433A1F93076Q27485988-776B90BB-DAB4-4949-BCC2-61D83FDDB732Q27485991-7E475087-F4B8-4F39-9B86-2CA41C6C6729Q27486027-515D1083-60EA-461D-B7F9-D6CF7B81B54FQ27486051-1F9D3E26-C9BE-4F3B-8626-89C903957245Q27486062-DD14C20B-DB39-442E-9A12-09EE768EA3A8Q27486070-462ABA85-0B48-45B5-B71A-B23421A4D428Q27486075-EEFDBD00-AA0D-4A52-AC9C-D964936CAB28Q27486196-D7E17013-03A2-47FD-BE17-F24F0B347B6D
P2860
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
description
1989 nî lūn-bûn
@nan
1989 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@ast
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@en
type
label
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@ast
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@en
prefLabel
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@ast
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@en
P1433
P1476
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses
@en
P2093
Fletterick RJ
P407
P577
1989-08-01T00:00:00Z