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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesGenetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease.Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesGene-pseudogene evolution: a probabilistic approachRare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWFDirectional dominance on stature and cognition in diverse human populationsLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibilityMultiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular diseaseSimultaneous Bayesian gene tree reconstruction and reconciliation analysis.Birth-death prior on phylogeny and speed datingGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityGenome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulationGenome-wide probabilistic reconciliation analysis across vertebrates.primetv: a viewer for reconciled treesMapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.Fast and general tests of genetic interaction for genome-wide association studies.Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune responseDLRS: gene tree evolution in light of a species tree.Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility lociThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.GenPhyloData: realistic simulation of gene family evolution.No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.New genetic loci link adipose and insulin biology to body fat distribution.Plasma IL-5 concentration and subclinical carotid atherosclerosis.Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests.The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysisSex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular DiseaseLarge-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.A gene-centric study of common carotid artery remodelling.A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistanceDiscovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke.Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media ThicknessIntegrating Sequence Evolution into Probabilistic Orthology Analysis.Analysis with the exome array identifies multiple new independent variants in lipid loci
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Zweeds onderzoeker
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