Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation - Wikidata - awgldk - TriplyDB

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

http://www.wikidata.org/entity/Q29999509

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The Warburg effect and drug resistance Protein Folding and Mechanisms of Proteostasis Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae.Tumor progression and the different faces of the PERK kinase Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells.Stress, inflammation, and defense of homeostasis Energy restriction as an antitumor target of thiazolidinediones.Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype.Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.Tumor bioenergetics: an emerging avenue for cancer metabolism targeted therapy Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo.Endoplasmic reticulum stress and cancer.Synergistic anti-cancer effect of phenformin and oxamate.Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts.Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells.GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma.Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes.RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells.Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis Additive Effects of Millimeter Waves and 2-Deoxyglucose Co-Exposure on the Human Keratinocyte Transcriptome.Cancer risk in HBV patients with statin and metformin use: a population-based cohort study.The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib.Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response.Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture Targeting the metabolic microenvironment of tumors.Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.ER stress inducer tunicamycin suppresses the self-renewal of glioma-initiating cell partly through inhibiting Sox2 translation.

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P2860

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

http://www.wikidata.org/entity/Q29999509

description

2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Chemical Genomics Identifies t ...... ing during Glucose Deprivation

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Chemical Genomics Identifies t ...... ing during Glucose Deprivation

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Chemical Genomics Identifies t ...... ing during Glucose Deprivation

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Chemical Genomics Identifies t ...... ing during Glucose Deprivation

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Cancer Research

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Chemical genomics identifies t ...... ing during glucose deprivation

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Aki Furuno

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Akihiro Tomida

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Asami Sakamoto

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Hae-Ryong Park

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Junko Sakurai

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Sakae Saito

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scholarly article

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10

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