Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation.
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STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triadsCongenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3.How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?Will you still need me (Ca2+ , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?Pharmacogenetics and pathophysiology of CACNA1S mutations in malignant hyperthermia.Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet.Structural insights into binding of STAC proteins to voltage-gated calcium channels.De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release.Stac3 enhances expression of human CaV1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels.STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation.STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex.Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1.Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus.Allosteric regulators selectively prevent Ca-feedback of Ca and Na channels
P2860
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P2860
Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation.
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@ast
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@en
type
label
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@ast
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@en
prefLabel
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@ast
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@en
P2093
P2860
P356
P1476
Stac3 has a direct role in ske ...... y a myopathy-causing mutation.
@en
P2093
Alexander Polster
Benjamin R Nelson
Eric N Olson
Kurt G Beam
P2860
P304
10986-10991
P356
10.1073/PNAS.1612441113
P407
P577
2016-09-12T00:00:00Z