about
Relationships between cancer and aging: a multilevel approachMARK-AGE population: From the human model to new insightsMARK-AGE biomarkers of ageingActivation-induced and damage-induced cell death in aging human T cellsAge-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE studyDesign, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) projectQuality control data of physiological and immunological biomarkers measured in serum and plasma.Proliferation and apoptosis of human T cells during replicative senescence--a critical approach.Curcumin, inflammation, ageing and age-related diseases.The promise of slow down ageing may come from curcumin.Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specificThe role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytesWhat evidence is there for the existence of individual genes with antagonistic pleiotropic effects?Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence.Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).High-resolution quantitative metabolome analysis of urine by automated flow injection NMR.Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature.Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study.A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta.NOX4 downregulation leads to senescence of human vascular smooth muscle cells.Is senescence-associated β-galactosidase a marker of neuronal senescence?Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.Impact of cellular senescence signature on ageing research.Morphological and Functional Characteristic of Senescent Cancer Cells.Is DNA damage indispensable for stress-induced senescence?Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project.Curcumin-treated cancer cells show mitotic disturbances leading to growth arrest and induction of senescence phenotype.Sirtuins, a promising target in slowing down the ageing process.Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage.Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21(waf1/cip1) expression and lack of polyploidy.Effect of curcumin on the apoptosis of rodent and human nonproliferating and proliferating lymphoid cells.A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells.The role of gender and labour status in immunosenescence of 65+ Polish population.The Future of Ageing: not more of the same.Interference between DNA binding activities of AP-1 and GR transcription factors in rat thymocytes undergoing dexamethasone-induced apoptosis.Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity.Role of annexin A6 isoforms in catecholamine secretion by PC12 cells: distinct influence on calcium response.
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hulumtuese
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polska biolog i biochemik
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հետազոտող
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P106
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Ewa Sikora
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P21
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0000-0002-1111-1748