about
Proinvasion metastasis drivers in early-stage melanoma are oncogenes.Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.Diacylglycerol kinase zeta regulates Ras activation by a novel mechanismKnockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo.Gene therapy for carcinoma of the breast: Genetic toxinsInducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermisConditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrencePreponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastasesCurrent State of Animal (Mouse) Modeling in Melanoma ResearchCurrent and future trials of targeted therapies in cutaneous melanomaHuman correlates of provocative questions in pancreatic pathologyMelanoma: from mutations to medicineMYC activation is a hallmark of cancer initiation and maintenanceActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsTumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RASIn silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interactionDiscovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated ActivationApproach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchangeA method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligandKRAS as prognostic biomarker in metastatic colorectal cancer patients treated with bevacizumab: a pooled analysis of 12 published trials.The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized careAdvances and Challenges on Cancer Cells Reprogramming Using Induced Pluripotent Stem Cells TechnologiesCharacterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and DeathRas-induced cellular events (review)RAS oncogenes: weaving a tumorigenic webInduction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genesDiacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signalingImmunoprevention of chemical carcinogenesis through early recognition of oncogene mutationsSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasPrinciples of cancer therapy: oncogene and non-oncogene addictionSelective inhibition of tumor oncogenes by disruption of super-enhancersAugmentation of tumor angiogenesis by a Myc-activated microRNA clusterIdentifying mutation specific cancer pathways using a structurally resolved protein interaction network.Noisy-threshold control of cell death.Survival and death signals can predict tumor response to therapy after oncogene inactivationHOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome.Integration of zebrafish fin regeneration genes with expression data of human tumors in silico uncovers potential novel melanoma markers.Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Essential role for oncogenic Ras in tumour maintenance.
@ast
Essential role for oncogenic Ras in tumour maintenance.
@en
type
label
Essential role for oncogenic Ras in tumour maintenance.
@ast
Essential role for oncogenic Ras in tumour maintenance.
@en
prefLabel
Essential role for oncogenic Ras in tumour maintenance.
@ast
Essential role for oncogenic Ras in tumour maintenance.
@en
P2093
P356
P1433
P1476
Essential role for oncogenic Ras in tumour maintenance.
@en
P2093
Bardeesy N
Cordon-Cardo C
DePinho RA
Horner JW 2nd
Pantginis J
Pomerantz J
P2888
P304
P356
10.1038/22788
P407
P577
1999-07-01T00:00:00Z
P6179
1011644064