Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.
about
EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological DisordersB cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2.The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions.Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity.Swiprosin-1 is a novel actin bundling protein that regulates cell spreading and migration.The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice.EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease.Monoclonal antibodies to discriminate the EF hand containing calcium binding adaptor proteins EFhd1 and EFhd2.Swiprosin-1 modulates actin dynamics by regulating the F-actin accessibility to cofilin.Structural implications of Ca2+-dependent actin-bundling function of human EFhd2/Swiprosin-1.Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice.Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system.EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction.Swiprosin-1: Its Expression and Diverse Biological Functions.Functional and structural analysis of the conserved EFhd2 protein.Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity.EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma.The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.Swiprosin-1 deficiency impairs macrophage immune response of septic mice.Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALLConserved Noncoding Sequences Boost ADR1 and SP1 Regulated Human Swiprosin-1 Promoter Activity
P2860
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P2860
Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.
description
2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@ast
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@en
type
label
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@ast
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@en
prefLabel
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@ast
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@en
P2093
P356
P1476
Swiprosin-1/EFhd2 controls B c ...... se C gamma2 in membrane rafts.
@en
P2093
Astrid Schweizer
Carmen Kroczek
Christiane Lang
Dirk Mielenz
Lars Nitschke
Marcus Grohmann
Sebastian Dütting
Stephan M Feller
P304
P356
10.4049/JIMMUNOL.0903642
P407
P577
2010-03-01T00:00:00Z