Molecular dynamics simulation of the SH3 domain aggregation suggests a generic amyloidogenesis mechanism.
about
Protein folding: then and nowPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)The interface of protein structure, protein biophysics, and molecular evolutionThermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approachesDiffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasmCrystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregationIntertwined dimeric structure for the SH3 domain of the c-Src tyrosine kinase induced by polyethylene glycol bindingAtomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and IIFormation of partially ordered oligomers of amyloidogenic hexapeptide (NFGAIL) in aqueous solution observed in molecular dynamics simulations.Phase diagrams describing fibrillization by polyalanine peptides.The role of Phe in the formation of well-ordered oligomers of amyloidogenic hexapeptide (NFGAIL) observed in molecular dynamics simulations with explicit solvent.Contrasting effects of nanoparticle-protein attraction on amyloid aggregationSpontaneous fibril formation by polyalanines; discontinuous molecular dynamics simulationsProbing protein aggregation using discrete molecular dynamicsElectrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formationPropensity to form amyloid fibrils is encoded as excitations in the free energy landscape of monomeric proteins.Microcanonical thermostatistics of coarse-grained proteins with amyloidogenic propensity.The redundancy of NMR restraints can be used to accelerate the unfolding behavior of an SH3 domain during molecular dynamics simulationsStability tests on known and misfolded structures with discrete and all atom molecular dynamics simulations.Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.Effect of beta-sheet propensity on peptide aggregation.Effects of frustration, confinement, and surface interactions on the dimerization of an off-lattice beta-barrel protein.Self-assembly of peptides into a beta-barrel motif.Detection and characterization of partially unfolded oligomers of the SH3 domain of alpha-spectrin.Conformational changes of alpha-chymotrypsin in a fibrillation-promoting condition: a molecular dynamics study.Three-dimensional domain swapping in the protein structure space.Simulation of pH-dependent edge strand rearrangement in human beta-2 microglobulin.The conserved lid tryptophan, W211, potentiates thermostability and thermoactivity in bacterial thermoalkalophilic lipasesbeta-Strand interactions at the domain interface critical for the stability of human lens gammaD-crystallinDirect observation of a single nanoparticle-ubiquitin corona formationDifferential hydrophobicity drives self-assembly in Huntington's disease.Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.Theoretical model of prion propagation: a misfolded protein induces misfolding.Protein-folding landscapes in multichain systems.Folding Trp-cage to NMR resolution native structure using a coarse-grained protein modelIn silico study of amyloid beta-protein folding and oligomerization.Biochemistry and clinical role of human cystatin C.Molecular simulations of mutually exclusive folding in a two-domain protein switch.Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.Interdomain communication revealed in the diabetes drug target mitoNEET
P2860
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P2860
Molecular dynamics simulation of the SH3 domain aggregation suggests a generic amyloidogenesis mechanism.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@ast
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@en
type
label
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@ast
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@en
prefLabel
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@ast
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@en
P50
P1476
Molecular dynamics simulation ...... ric amyloidogenesis mechanism.
@en
P304
P356
10.1016/S0022-2836(02)01112-9
P407
P577
2002-12-01T00:00:00Z