The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding.
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Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variantsCoactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 productionCrystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysisLocation, location, location: compartmentalization of early events in leukotriene biosynthesis.Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenaseProgrammed chloroplast destruction during leaf senescence involves 13-lipoxygenase (13-LOX)15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.Industrial potential of lipoxygenases.Low density lipoprotein receptor-related protein-mediated membrane translocation of 12/15-lipoxygenase is required for oxidation of low density lipoprotein by macrophages.Applicability of the triad concept for the positional specificity of mammalian lipoxygenases.Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.Enzyme 15-lipoxygenase 1 promotes hypoxia-inducible factor 1α turnover and reduces vascular endothelial growth factor expression: implications for angiogenesis.Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2.Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition.Structure-to-function relationship of mini-lipoxygenase, a 60-kDa fragment of soybean lipoxygenase-1 with lower stability but higher enzymatic activity.Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium.Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality.A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality.Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?Overproduction, purification, and characterization of extracellular lipoxygenase of Pseudomonas aeruginosa in Escherichia coli.
P2860
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P2860
The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The N-terminal domain of the r ...... rminants for membrane binding.
@ast
The N-terminal domain of the r ...... rminants for membrane binding.
@en
type
label
The N-terminal domain of the r ...... rminants for membrane binding.
@ast
The N-terminal domain of the r ...... rminants for membrane binding.
@en
prefLabel
The N-terminal domain of the r ...... rminants for membrane binding.
@ast
The N-terminal domain of the r ...... rminants for membrane binding.
@en
P2093
P2860
P356
P1476
The N-terminal domain of the r ...... rminants for membrane binding.
@en
P2093
Hartmut Kuhn
Martin Wiedmann
Matthias Walther
Monika Anton
Robert Fletterick
P2860
P304
27360-27366
P356
10.1074/JBC.M203234200
P407
P577
2002-05-09T00:00:00Z