Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
about
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifThe Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGFBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerCytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalinThe Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling propertiesEvolution of SH2 domains and phosphotyrosine signalling networksGrb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxelTyrosine kinase signalling in breast cancer: modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates.Tyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer.The transcriptional regulation of pluripotencyCell lineage allocation within the inner cell mass of the mouse blastocystTroika of the mouse blastocyst: lineage segregation and stem cellsIntercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axesCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaThe adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrierDirected Network Wiring Identifies a Key Protein Interaction in Embryonic Stem Cell DifferentiationMolecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency networkInteraction domains: from simple binding events to complex cellular behaviorLeukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytesThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifSam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasisThe SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotesShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigenTyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cellsFunctions of HNF1 family members in differentiation of the visceral endoderm cell lineageSox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewalThe Grb2/Mek pathway represses Nanog in murine embryonic stem cellsRole of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activationShcA signalling is essential for tumour progression in mouse models of human breast cancerPrPC directly interacts with proteins involved in signaling pathwaysRNA-seq analysis of single bovine blastocystsMolecular cloning and characterization of growth factor receptor bound-protein in Clonorchis sinensis.Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interactionGrb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selectionShort-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesisgrb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis.
P2860
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P2860
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Mammalian Grb2 regulates multi ...... and malignant transformation.
@ast
Mammalian Grb2 regulates multi ...... and malignant transformation.
@en
type
label
Mammalian Grb2 regulates multi ...... and malignant transformation.
@ast
Mammalian Grb2 regulates multi ...... and malignant transformation.
@en
prefLabel
Mammalian Grb2 regulates multi ...... and malignant transformation.
@ast
Mammalian Grb2 regulates multi ...... and malignant transformation.
@en
P2093
P1433
P1476
Mammalian Grb2 regulates multi ...... t and malignant transformation
@en
P2093
C G Tortorice
R D Cardiff
S Kulkarni
T M Saxton
W J Muller
P304
P356
10.1016/S0092-8674(00)81702-X
P407
P577
1998-12-01T00:00:00Z