Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.
about
Interaction of Hic-5, A senescence-related protein, with focal adhesion kinaseCharacterization of GFR, a novel guanine nucleotide exchange factor for Rap1Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein CrkDirect binding of p130(Cas) to the guanine nucleotide exchange factor C3GTyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substratesInteraction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesisA direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activationHic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinaseA p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signalingPhosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeletonThe Role of Crk Adaptor Proteins in T-Cell Adhesion and MigrationSignaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKLPhysical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domainT cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3GInterplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transductionPhosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesisCrk activation of JNK via C3G and R-RasIdentification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing moleculesSignalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformationCrkII induces serum response factor activation and cellular transformation through its function in Rho activation.v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras.v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.Cas mediates transcriptional activation of the serum response element by Src.The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathwayActivation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein.Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi's sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cellsProtein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceActivation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells.c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation.Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases.Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha.ROS, stress-activated kinases and stress signaling in cancer.The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons.Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle.
P2860
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P2860
Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@ast
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@en
type
label
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@ast
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@en
prefLabel
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@ast
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@en
P2093
P2860
P356
P1476
Downstream of Crk adaptor sign ...... cleotide exchange protein C3G.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.6.2356
P407
P577
1997-03-01T00:00:00Z