Adaptive hypersensitivity following long-term estrogen deprivation: involvement of multiple signal pathways.
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Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesAdenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells.Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells.Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells.Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells.Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment.Aromatase is phosphorylated in situ at serine-118.Optimizing the use of neoadjuvant endocrine therapy.Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer.COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast cancer cellsAnti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotargetGrowth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms.Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studiesTreatment of HER2-positive metastatic breast cancer following initial progression.Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interactionTrastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen.Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cellsLead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.Mechanisms of hormonal therapy resistance in breast cancer.Effect of selumetinib on the growth of anastrozole-resistant tumors.Aromatase overexpression induces malignant changes in estrogen receptor α negative MCF-10A cells.Everolimus and its role in hormone-resistant and trastuzumab-resistant metastatic breast cancer.Biological reprogramming in acquired resistance to endocrine therapy of breast cancer.Crosstalk with insulin and dependence on PI3K/Akt/mTOR rather than MAPK pathways in upregulation of basal growth following long-term oestrogen deprivation in three human breast cancer cell lines.Everolimus in combination with letrozole inhibit human breast cancer MCF-7/Aro stem cells via PI3K/mTOR pathway: an experimental study.A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.Acquired resistance to everolimus in aromatase inhibitor-resistant breast cancer.
P2860
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P2860
Adaptive hypersensitivity following long-term estrogen deprivation: involvement of multiple signal pathways.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@ast
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@en
type
label
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@ast
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@en
prefLabel
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@ast
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@en
P2093
P1476
Adaptive hypersensitivity foll ...... t of multiple signal pathways.
@en
P2093
Ji-Ping Wang
Mark R Conaway
Richard J Santen
P304
P356
10.1016/S0960-0760(03)00366-2
P577
2003-09-01T00:00:00Z