Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.
about
Inhibition of EZH2 degradation as a novel approach to overcome drug resistance in acute myeloid leukemia.MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner.Role of epigenetics-microRNA axis in drug resistance of multiple myeloma.Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice.The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells.Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML.The molecular signature of AML with increased ALDH activity suggests a stem cell origin.Cytarabine and daunorubicin for the treatment of acute myeloid leukemia.Distinct histone modifications denote early stress-induced drug tolerance in cancer.Enhancer of zeste homolog 2 promotes cisplatin resistance by reducing cellular platinum accumulation.Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential.Frequent epigenetic alterations in polycomb repressive complex 2 in osteosarcoma cell lines.miR-451a abrogates treatment resistance in FLT3-ITD-positive acute myeloid leukemia.Integrative Bioinformatics Analysis Reveals Potential Long Non-Coding RNA Biomarkers and Analysis of Function in Non-Smoking Females with Lung Cancer
P2860
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P2860
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.
description
2016 nî lūn-bûn
@nan
2016 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@ast
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@en
type
label
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@ast
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@en
prefLabel
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@ast
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@en
P2093
P2860
P50
P356
P1433
P1476
Loss of the histone methyltran ...... ugs in acute myeloid leukemia.
@en
P2093
Arthur Zelent
Caroline Pabst
Christian Rohde
Christian Thiede
Claudia Wickenhauser
Friedrich Stölzel
Gabriele Köhler
Hans-Ulrich Klein
Henning Urlaub
Karsten Spiekermann
P2860
P2888
P356
10.1038/NM.4247
P407
P577
2016-12-12T00:00:00Z