Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides.
about
The effect of radiation-induced reactive oxygen species (ROS) on the structural and functional properties of yeast alcohol dehydrogenase (YADH).P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors.The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sitesCharacterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysisThe multi-structural feature of the multidrug resistance gene product P-glycoprotein: implications for its mechanism of action (hypothesis).ABC multidrug transporters: structure, function and role in chemoresistance.Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscsKinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2.Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein.P-glycoprotein is fully active after multiple tryptophan substitutionsOn the origin of large flexibility of P-glycoprotein in the inward-facing stateReversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport.Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter.Tryptophan fluorescence quenching as a binding assay to monitor protein conformation changes in the membrane of intact mitochondria.Detergent-free purification of ABC (ATP-binding-cassette) transporters.Interaction of the 18.5-kD isoform of myelin basic protein with Ca2+ -calmodulin: effects of deimination assessed by intrinsic Trp fluorescence spectroscopy, dynamic light scattering, and circular dichroism.Modulation of P-glycoprotein ATPase of Helicoverpa armigera by cholesterol: effects on ATPase activity and interaction of insecticides.New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers.Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.Molecular dynamics simulations of E. coli MsbA transmembrane domain: formation of a semipore structureThree-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics.S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1).Neither lipophilicity nor membrane-perturbing potency of phenothiazine maleates correlate with the ability to inhibit P-glycoprotein transport activity.Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).Modulatory Effect of Citrate Reduced Gold and Biosynthesized Silver Nanoparticles on α-Amylase Activity
P2860
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P2860
Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides.
description
2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@ast
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@en
type
label
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@ast
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@en
prefLabel
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@ast
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@en
P2093
P356
P1433
P1476
Intrinsic fluorescence of the ...... ding of drugs and nucleotides.
@en
P2093
P304
14927-14938
P356
10.1021/BI0018786
P407
P577
2000-12-01T00:00:00Z