about
A high-resolution anatomical atlas of the transcriptome in the mouse embryoTwo novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosisUbxd1 is a novel co-factor of the human p97 ATPaseThe retroviral proteinase active site and the N-terminus of Ddi1 are required for repression of protein secretion.Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.Lsh regulates LTR retrotransposon repression independently of Dnmt3b function.The circadian dynamics of small nucleolar RNA in the mouse liverSequence-level mechanisms of human epigenome evolution.Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acidConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studiesA promoter-level mammalian expression atlasThe genomic signature of trait-associated variants.Divergence of mammalian higher order chromatin structure is associated with developmental loci.Side effects: substantial non-neutral evolution flanking regulatory sitesProperties of local interactions and their potential value in complementing genome-wide association studies.The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.New ATPase regulators--p97 goes to the PUB.Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformationsTranscriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response.Widespread signatures of recent selection linked to nucleosome positioning in the human lineage.Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization.Homozygous loss-of-function variants in European cosmopolitan and isolate populationsA genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci.The changing of the guard: Molecular diversity and rapid evolution of beta-defensins.Posttranscriptional regulation of miRNAs harboring conserved terminal loops.Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.When TADs go bad: chromatin structure and nuclear organisation in human diseaseHuman β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIFThioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasomeHigh-throughput analysis of epistasis in genome-wide association studies with BiForce.Opening sequence: computational genomics in the era of high-throughput sequencing.Characterisation of the nascent polypeptide-associated complex in fission yeast.Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.Maintenance of inversion polymorphism in Drosophila melanogasterCorrigendum: Genome-wide analysis of mammalian promoter architecture and evolutionCorrigendum of 'High throughput analysis of epistasis in genome-wide association studies with BiForce'Modelling double strand break susceptibility to interrogate structural variation in cancerChromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
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description
Professor and Head of Bioinfor ...... at the University of Edinburgh
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onderzoeker
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Colin A Semple
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Colin A Semple
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Colin A. Semple
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Colin A. Semple
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Colin Semple
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Colin A Semple
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Colin A Semple
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Colin A. Semple
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Colin A. Semple
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Colin Semple
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Colin A Semple
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Colin A. M. Semple
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Colin Semple
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Colin A Semple
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Colin A Semple
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Colin A. Semple
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Colin A. Semple
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Colin Semple
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P106
P1153
7006977465
P1960
h9QWiJIAAAAJ
P21
P2456
P31
P496
0000-0003-1765-4118
P569
2000-01-01T00:00:00Z