Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine.
about
Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine andt-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chainsStructural basis for the enhanced stability of highly fluorinated proteinsMolecular dynamics guided study of salt bridge length dependence in both fluorinated and non-fluorinated parallel dimeric coiled-coils.Rational design of protein stability: effect of (2S,4R)-4-fluoroproline on the stability and folding pathway of ubiquitinHydration dynamics at fluorinated protein surfacesEvolution of a fluorinated green fluorescent protein.Solution structure of a small protein containing a fluorinated side chain in the coreIntegrating the discovery pipeline for novel compounds targeting ion channels.The fluorous effect in biomolecular applications.Fluorinated amino acids: compatibility with native protein structures and effects on protein-protein interactions.Fluorine: a new element in protein design.Non-additive stabilization by halogenated amino acids reveals protein plasticity on a sub-angstrom scale.Modulating the structure of phenylalanine-incorporated ascidiacyclamide through fluorination.Biosynthesis and stability of coiled-coil peptides containing (2S,4R)-5,5,5-trifluoroleucine and (2S,4S)-5,5,5-trifluoroleucine.Organic fluorine as a polypeptide building element: in vivo expression of fluorinated peptides, proteins and proteomes.Enantioselective synthesis of (2R, 3S)- and (2S, 3R)-4,4,4-trifluoro-N-Fmoc-O-tert-butyl-threonine and their racemization-free incorporation into oligopeptides via solid-phase synthesis.(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline: two conformationally distinct proline amino acids for sensitive application in 19F NMR.Synthesis of enantiomerically pure (2S,3S)-5,5,5-trifluoroisoleucine and (2R,3S)-5,5,5-trifluoro-allo-isoleucine.Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe.Self-assembly is prerequisite for catalysis of Fe(II) oxidation by catalytically active subunits of ferritin.A New Paradigm for Protein Design and Biological Self-Assembly.Multi-component synthesis of peptide-sugar conjugates.Suzuki-Miyaura Cross-Coupling Reactions of Highly Fluorinated Arylboronic Esters: Catalytic Studies and Stoichiometric Model Reactions on the Transmetallation Step.Protein-observed (19)F-NMR for fragment screening, affinity quantification and druggability assessment.Remodeling a β-peptide bundleFluorinated amino acids in amyloid formation: a symphony of size, hydrophobicity and α-helix propensity
P2860
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P2860
Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Modulating protein structure w ...... protein by hexafluoroleucine.
@ast
Modulating protein structure w ...... protein by hexafluoroleucine.
@en
type
label
Modulating protein structure w ...... protein by hexafluoroleucine.
@ast
Modulating protein structure w ...... protein by hexafluoroleucine.
@en
prefLabel
Modulating protein structure w ...... protein by hexafluoroleucine.
@ast
Modulating protein structure w ...... protein by hexafluoroleucine.
@en
P2093
P356
P1476
Modulating protein structure w ...... e protein by hexafluoroleucine
@en
P2093
Hashim M Al-Hashimi
Hyang-Yeol Lee
Kyung-Hoon Lee
P304
P356
10.1021/JA0563410
P407
P50
P577
2006-01-01T00:00:00Z