The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus.
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Transmission of H7N9 influenza viruses with a polymorphism at PB2 residue 627 in chickens and ferretsGenetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 Avian Influenza virusesInfluenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potentialEvaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant culturesAnalysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmissionMammalian models for the study of H7 virus pathogenesis and transmission.Molecular determinants of influenza virus pathogenesis in mice.Characteristic amino acid changes of influenza A(H1N1)pdm09 virus PA protein enhance A(H7N9) viral polymerase activity.Two Outbreak Sources of Influenza A (H7N9) Viruses Have Been Established in ChinaSusceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus)The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage.Novel influenza A(H7N2) virus in chickens, Jilin province, China, 2014.The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication.Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection.Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts.A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report.A live attenuated vaccine prevents replication and transmission of H7N9 virus in mammals.Genomic Signatures for Avian H7N9 Viruses Adapting to Humans.Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models.Molecular Determinants of Virulence and Stability of a Reporter-Expressing H5N1 Influenza A VirusAssessment of Antiviral Properties of Peramivir against H7N9 Avian Influenza Virus in an Experimental Mouse Model.Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China.PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesGenetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review.Altered virulence of Highly Pathogenic Avian Influenza (HPAI) H5N8 reassortant viruses in mammalian models.Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Genetic and codon usage bias analyses of polymerase genes of equine influenza virus and its relation to evolution.Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.Novel H7N2 and H5N6 Avian Influenza A Viruses in Sentinel Chickens: A Sentinel Chicken Surveillance Study.Amino Acid Substitutions Associated with Avian H5N6 Influenza A Virus Adaptation to MiceA single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence.Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts.H7N9 virulent mutants detected in chickens in China pose an increased threat to humans.Dynamic Variation and Reversion in the Signature Amino Acids of H7N9 Virus During Human Infection.The Drivers of Pathology in Zoonotic Avian Influenza: The Interplay Between Host and PathogenA live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammalsDeep Sequencing of H7N9 Influenza A Viruses from 16 Infected Patients from 2013 to 2015 in Shanghai Reveals Genetic Diversity and Antigenic DriftThe Pandemic Threat of Emerging H5 and H7 Avian Influenza Viruses
P2860
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P2860
The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@ast
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@en
type
label
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@ast
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@en
prefLabel
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@ast
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@en
P2093
P356
P1476
The PB2 E627K mutation contrib ...... ation of H7N9 influenza virus.
@en
P2093
Chong Chang
Hong Zhang
Hualan Chen
Yuanyuan Li
P304
P356
10.1099/VIR.0.061721-0
P407
P577
2014-01-06T00:00:00Z