Discovery and characterization of small molecules that target the GTPase Ral - Wikidata - awgldk - TriplyDB

Discovery and characterization of small molecules that target the GTPase Ral

Discovery and characterization of small molecules that target the GTPase Ral

http://www.wikidata.org/entity/Q30366783

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Genetics and biology of pancreatic ductal adenocarcinoma Ral GTPases: crucial mediators of exocytosis and tumourigenesis Synthesis of novel Ral inhibitors: An in vitro and in vivo study Docking Screens for Novel Ligands Conferring New Biology.RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1 The nuts and bolts of the platelet release reaction.Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.Drugging the Ral GTPase.Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.TATA boxes in gene transcription and poly (A) tails in mRNA stability: New perspective on the effects of berberine.EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer Constructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery.eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy.Therapeutic Approaches to RAS Mutation.RalA, a GTPase targeted by miR-181a, promotes transformation and progression by activating the Ras-related signaling pathway in chronic myelogenous leukemia.RALB provides critical survival signals downstream of Ras in acute myeloid leukemia The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.Direct Modulation of Small GTPase Activity and Function.Inhibition of Ral GTPases Using a Stapled Peptide Approach.Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies.Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner.Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models.One step closer to targeting RAS.Alpha 7 nicotinic receptor coupling to heterotrimeric G proteins modulates RhoA activation, cytoskeletal motility, and structural growth.Ral signaling pathway in health and cancer.RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers.Targeting Ras signaling in AML: RALB is a small GTPase with big potential.Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers.Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer.A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc.Understanding the biology of urothelial cancer metastasis.New Approaches to Difficult Drug Targets: The Phosphatase Story Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

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Discovery and characterization of small molecules that target the GTPase Ral

http://www.wikidata.org/entity/Q30366783

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

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2014年論文

@zh-tw

2014年论文

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name

Discovery and characterization of small molecules that target the GTPase Ral

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Discovery and characterization of small molecules that target the GTPase Ral

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type

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Discovery and characterization of small molecules that target the GTPase Ral

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Discovery and characterization of small molecules that target the GTPase Ral

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prefLabel

Discovery and characterization of small molecules that target the GTPase Ral

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Discovery and characterization of small molecules that target the GTPase Ral

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Discovery and characterization of small molecules that target the GTPase Ral

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Brenton Hoffman

http://www.w3.org/2001/XMLSchema#string

Bryce M Paschal

http://www.w3.org/2001/XMLSchema#string

Chao Yan

http://www.w3.org/2001/XMLSchema#string

Charles Owens

http://www.w3.org/2001/XMLSchema#string

Christina L Wysoczynski

http://www.w3.org/2001/XMLSchema#string

Dan Theodorescu

http://www.w3.org/2001/XMLSchema#string

David L Brautigan

http://www.w3.org/2001/XMLSchema#string

David N M Jones

http://www.w3.org/2001/XMLSchema#string

David Ross

http://www.w3.org/2001/XMLSchema#string

Degang Liu

http://www.w3.org/2001/XMLSchema#string

P2860

RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling

Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

ZINC--a free database of commercially available compounds for virtual screening

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

The CCPN data model for NMR spectroscopy: development of a software pipeline

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443-447

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scholarly article

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10.1038/NATURE13713

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7527

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515

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2014-09-14T00:00:00Z

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265647698

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25219851

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4351747

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