Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
about
New small-molecule drug design strategies for fighting resistant influenza AProgress of small molecular inhibitors in the development of anti-influenza virus agents.Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.Acid activation mechanism of the influenza A M2 proton channel.On the role of water density fluctuations in the inhibition of a proton channelInfluenza A Virus Nucleoprotein: A Highly Conserved Multi-Functional Viral Protein as a Hot Antiviral Drug Target.Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy.Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel.Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier of drug resistancePharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers.Crystal structure of the drug-resistant S31N influenza M2 proton channel.Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors.Binding pathway analysis of influenza virus M2 channel blockers by metadynamics simulation.An Optically Active Polymer for Broad-Spectrum Enantiomeric Recognition of Chiral Acids.Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses.Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways.Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers.Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7.
P2860
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P2860
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
description
2014 nî lūn-bûn
@nan
2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
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2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
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2014年论文
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name
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@ast
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@en
type
label
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@ast
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@en
prefLabel
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@ast
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@en
P2093
P2860
P356
P1476
Flipping in the pore: discover ...... nza A virus M2 proton channel.
@en
P2093
Belgin Canturk
Chunlong Ma
Eleonora Gianti
Giacomo Fiorin
Lawrence H Pinto
Michael L Klein
Robert A Lamb
P2860
P304
17987-17995
P356
10.1021/JA508461M
P407
P577
2014-12-18T00:00:00Z