Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss.
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Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss - A Common Hereditary Deafness.The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.Hypothesis of K+-Recycling Defect Is Not a Primary Deafness Mechanism for Cx26 (GJB2) DeficiencySound-Induced Intracellular Ca2+ Dynamics in the Adult Hearing CochleaPannexin 1 deficiency can induce hearing lossReduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin MicePannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing.Characterization of a knock-in mouse model of the homozygous p.V37I variant in Gjb2.A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall.Molecular composition and distribution of gap junctions in the sensory epithelium of the human cochlea-a super-resolution structured illumination microscopy (SR-SIM) study.Progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing.Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development.Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus).Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in the GJB2 knockdown mouse model.ATP-Evoked Intracellular Ca²⁺ Signaling of Different Supporting Cells in the Hearing Mouse Hemicochlea.Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness.Knockout of Pannexin-1 Induces Hearing Loss.Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice
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P2860
Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss.
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2014 nî lūn-bûn
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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@ast
Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@en
type
label
Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@ast
Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@en
prefLabel
Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@ast
Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@en
P2093
P2860
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Connexin26 (GJB2) deficiency r ...... ng to late-onset hearing loss.
@en
P2093
P2860
P304
P356
10.1016/J.NEUROSCIENCE.2014.10.061
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P577
2014-11-05T00:00:00Z