Computational protein design to reengineer stromal cell-derived factor-1α generates an effective and translatable angiogenic polypeptide analog.
about
Spatially oriented, temporally sequential smooth muscle cell-endothelial progenitor cell bi-level cell sheet neovascularizes ischemic myocardium.Normalization of postinfarct biomechanics using a novel tissue-engineered angiogenic construct.Sustained release of engineered stromal cell-derived factor 1-α from injectable hydrogels effectively recruits endothelial progenitor cells and preserves ventricular function after myocardial infarction.Mathematically engineered stromal cell-derived factor-1α stem cell cytokine analog enhances mechanical properties of infarcted myocardium.Preclinical evaluation of the engineered stem cell chemokine stromal cell-derived factor 1α analog in a translational ovine myocardial infarction model.Myocardial tissue elastic properties determined by atomic force microscopy after stromal cell-derived factor 1α angiogenic therapy for acute myocardial infarction in a murine model.A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy.Bioengineered stromal cell-derived factor-1α analogue delivered as an angiogenic therapy significantly restores viscoelastic material properties of infarcted cardiac muscleBiochemically engineered stromal cell-derived factor 1-alpha analog increases perfusion in the ischemic hind limb.A Tissue-Engineered Chondrocyte Cell Sheet Induces Extracellular Matrix Modification to Enhance Ventricular Biomechanics and Attenuate Myocardial Stiffness in Ischemic Cardiomyopathy.The development and characterization of SDF1α-elastin-like-peptide nanoparticles for wound healing.Protein engineering for cardiovascular therapeutics: untapped potential for cardiac repair.Addition of mesenchymal stem cells enhances the therapeutic effects of skeletal myoblast cell-sheet transplantation in a rat ischemic cardiomyopathy model.Therapeutic potential of Rb phosphorylation in atherosclerosis.VEGF treatment promotes bone marrow-derived CXCR4+ mesenchymal stromal stem cell differentiation into vessel endothelial cells.New vessels after stroke: postischemic neovascularization and regeneration.Re-engineered stromal cell-derived factor-1α and the future of translatable angiogenic polypeptide design.Concise review: the potential of stromal cell-derived factor 1 and its receptors to promote stem cell functions in spinal cord repair.Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization.Injectable Bioengineered Hydrogel Therapy in the Treatment of Ischemic Cardiomyopathy.Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice.Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application.SDF-1 liposomes promote sustained cell proliferation in mouse diabetic wounds.CXCL12/CXCR4/CXCR7 Chemokine Axis in the Central Nervous System: Therapeutic Targets for Remyelination in Demyelinating Diseases.SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells.
P2860
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P2860
Computational protein design to reengineer stromal cell-derived factor-1α generates an effective and translatable angiogenic polypeptide analog.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Computational protein design t ...... angiogenic polypeptide analog.
@ast
Computational protein design t ...... angiogenic polypeptide analog.
@en
type
label
Computational protein design t ...... angiogenic polypeptide analog.
@ast
Computational protein design t ...... angiogenic polypeptide analog.
@en
prefLabel
Computational protein design t ...... angiogenic polypeptide analog.
@ast
Computational protein design t ...... angiogenic polypeptide analog.
@en
P2093
P2860
P1433
P1476
Computational protein design t ...... angiogenic polypeptide analog.
@en
P2093
Elaine C Yang
J Raymond Fitzpatrick
Jeffrey R Muenzer
John R Frederick
John W Macarthur
Jose Manuel Perez-Aguilar
Li-Jun Yuan
Nicole A Marotta
Pavan Atluri
Ryan C McCormick
P2860
P304
P356
10.1161/CIRCULATIONAHA.110.009431
P407
P433
P577
2011-09-01T00:00:00Z