Structure-based drug design: progress, results and challenges.
about
Relating structure to thermodynamics: The crystal structures and binding affinity of eight OppA-peptide complexesDiamond: shedding light on structure-based drug discoveryeMatchSite: sequence order-independent structure alignments of ligand binding pockets in protein modelsProtein crystallography and infectious diseases.Class-directed structure determination: foundation for a protein structure initiativeDiscovering novel ligands for macromolecules using X-ray crystallographic screening.Macromolecular crystallography as a tool for investigating drug, enzyme and receptor interactions.Screening Analogs of β-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2.A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor designMapping the active site of CD59From local structure to a global framework: recognition of protein folds.Drug targets in Leishmania.A structurally conserved water molecule in Rossmann dinucleotide-binding domains.Advantages of Structure-Based Drug design Approaches in Neurological Disorders.Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite.Structural features of the carbon-sulfur chemical bond: a semi-experimental perspective.The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.Testing and validation of the Automated Topology Builder (ATB) version 2.0: prediction of hydration free enthalpies.Use of the multiple copy simultaneous search (MCSS) method to design a new class of picornavirus capsid binding drugs.Empirical free energy as a target function in docking and design: application to HIV-1 protease inhibitors.Carbohydrate inhibitors of cholera toxin.Monte Carlo algorithms for docking to proteins
P2860
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P2860
Structure-based drug design: progress, results and challenges.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Structure-based drug design: progress, results and challenges.
@ast
Structure-based drug design: progress, results and challenges.
@en
type
label
Structure-based drug design: progress, results and challenges.
@ast
Structure-based drug design: progress, results and challenges.
@en
prefLabel
Structure-based drug design: progress, results and challenges.
@ast
Structure-based drug design: progress, results and challenges.
@en
P1433
P1476
Structure-based drug design: progress, results and challenges.
@en
P2093
P304
P356
10.1016/S0969-2126(00)00060-5
P577
1994-07-01T00:00:00Z