Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.
about
Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating ModuleDirect inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7.Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7.N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7Epigenetic regulation of retinal development and disease.Polyglutamine (polyQ) disorders: the chromatin connection.Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteinsAcetyltransferases (HATs) as targets for neurological therapeuticsConsensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.Genetic syndromes caused by mutations in epigenetic genes.Functions of SAGA in development and disease.Histone modifying enzymes: novel disease biomarkers and assay development.Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development.The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies.
P2860
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P2860
Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Gcn5 loss-of-function accelera ...... eration in a SCA7 mouse model.
@ast
Gcn5 loss-of-function accelera ...... eration in a SCA7 mouse model.
@en
type
label
Gcn5 loss-of-function accelera ...... eration in a SCA7 mouse model.
@ast
Gcn5 loss-of-function accelera ...... eration in a SCA7 mouse model.
@en
prefLabel
Gcn5 loss-of-function accelera ...... eration in a SCA7 mouse model.
@ast
Gcn5 loss-of-function accelera ...... eration in a SCA7 mouse model.
@en
P2093
P2860
P50
P356
P1476
Gcn5 loss-of-function accelera ...... neration in a SCA7 mouse model
@en
P2093
Chai-An Mao
Rebecca W Lewis
Yi Chun Chen
P2860
P304
P356
10.1093/HMG/DDR474
P577
2011-10-14T00:00:00Z