Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.
about
Loss and recovery of genetic diversity in adapting populations of HIVLeveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion RatesGenome evolution by matrix algorithms: cellular automata approach to population genetics.Genome-wide inference of ancestral recombination graphs.A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis.Quantifying realized inbreeding in wild and captive animal populations.Demography and the age of rare variants.The utility of ancient human DNA for improving allele age estimates, with implications for demographic models and tests of natural selection.The genetics of microdeletion and microduplication syndromes: an update.Using diverse U.S. beef cattle genomes to identify missense mutations in EPAS1, a gene associated with pulmonary hypertension.Discovery, genotyping and characterization of structural variation and novel sequence at single nucleotide resolution from de novo genome assemblies on a population scaleGene hunting in autism spectrum disorder: on the path to precision medicineReflections on the Field of Human Genetics: A Call for Increased Disease Genetics TheoryLong runs of homozygosity are enriched for deleterious variation.Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Population growth inflates the per-individual number of deleterious mutations and reduces their mean effect.The standing pool of genomic structural variation in a natural population of Mimulus guttatus.Increased substitution rates surrounding low-complexity regions within primate proteins.Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.Allele Age Under Non-Classical Assumptions is Clarified by an Exact Computational Markov Chain Approach.Selective Strolls: Fixation and Extinction in Diploids Are Slower for Weakly Selected Mutations Than for Neutral OnesGenes with monoallelic expression contribute disproportionately to genetic diversity in humansCrossing-over in a hypervariable species preferentially occurs in regions of high local similarity.Europeans have a higher proportion of high‑frequency deleterious variants than Africans.Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland
P2860
Q28539052-5ABF1F8B-9C73-445C-98C1-F0060B81B833Q28604268-15B7F89C-0479-4516-B75C-F01332F1ACA3Q30577425-AEEF196E-2DF8-4F4E-A685-DE1372F857FCQ33617867-6F8CF74F-3AA4-482D-A733-64BB30861BBCQ34415749-F0EE6FD9-AC52-4EAE-B341-441187C1B0ABQ35178459-FF2FC7AF-B1E1-42AC-81A4-8B5C62F55C42Q35220923-EF4C9994-2DB7-433C-8DC2-743644862E07Q35240144-6A3DE012-AE70-4D43-8456-335765CACADCQ35765523-29EEB81B-2C8E-46B7-87B5-920279E93DD8Q36164665-16D43C1A-16C2-4D45-8928-5A84D74D6503Q36401823-167048C7-39A0-4C44-8C18-6CBB38AB9B85Q36412509-8FB61806-61BB-4908-97CE-5A635F716659Q36978721-04F9D665-354C-4BC3-B560-DB56C8DF93BCQ37010445-669E12EC-86C0-4ADC-BB94-A4463D74ADEFQ37261995-C68E8F86-A6FC-4A55-9B63-FAAFF569689AQ37269846-5495795B-5D90-4C1F-99BB-D96C766D13D6Q37557685-47D76BF5-5494-47FC-85D8-B5C5FE547177Q38578409-32A81043-6204-48EA-9ADA-3EBCD966884EQ40047884-96AFC339-DC9B-47FD-B793-E9AB363D1A9BQ41717458-AF047EFC-E2FA-4C6D-A8F8-0AC457E65D98Q41936407-48A1C57B-13C6-4E1A-8BC4-D474F0D4F0C8Q42424798-B7EE1518-3F26-49BC-A71F-CD7552FB2CA9Q42961134-DA844B03-7778-4B6A-B422-DD83AAC597E0Q53786447-934C51B6-547B-473E-AF3F-43AA908D5F18Q57255465-44A2CE81-5423-4C62-820D-544B7270361B
P2860
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Deleterious alleles in the hum ...... alleles of the same frequency.
@ast
Deleterious alleles in the hum ...... alleles of the same frequency.
@en
type
label
Deleterious alleles in the hum ...... alleles of the same frequency.
@ast
Deleterious alleles in the hum ...... alleles of the same frequency.
@en
prefLabel
Deleterious alleles in the hum ...... alleles of the same frequency.
@ast
Deleterious alleles in the hum ...... alleles of the same frequency.
@en
P2093
P2860
P50
P1433
P1476
Deleterious alleles in the hum ...... alleles of the same frequency.
@en
P2093
Freerk van Dijk
G J B van Ommen
Genome of the Netherlands Consortium
Laurent C Francioli
P Eline Slagboom
Paul I W de Bakker
Shamil R Sunyaev
P2860
P304
P356
10.1371/JOURNAL.PGEN.1003301
P577
2013-02-28T00:00:00Z