Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. - Wikidata - awgldk - TriplyDB

Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.

Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.

http://www.wikidata.org/entity/Q30430757

about

PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction Genetic Rodent Models of Obesity-Associated Ovarian Dysfunction and Subfertility: Insights into Polycystic Ovary Syndrome Obesity and PCOS: implications for diagnosis and treatment Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice.Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility.Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice.Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.Childhood obesity and its impact on the development of adolescent PCOS.Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.Selective breeding of mice for different susceptibilities to high fat diet-induced glucose intolerance: Development of two novel mouse lines, Selectively bred Diet-induced Glucose intolerance-Prone and -Resistant.Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice.Insulin action in brain regulates systemic metabolism and brain function.The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1).Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: insight from animal models Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes.Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models Forkhead Box O1 is present in quiescent pituitary cells during development and is increased in the absence of p27 Kip1 FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes.Vaginal fold histology reduces the variability introduced by vaginal exfoliative cytology in the classification of mouse estrous cycle stages Reproductive tissues maintain insulin sensitivity in diet-induced obesity.Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.The forkhead transcription factor, FOXP3, is required for normal pituitary gonadotropin expression in mice The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells.FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model A novel reproductive peptide, phoenixin.Integrative control of energy balance and reproduction in females.Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens.Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism.Metabolic influences on neuroendocrine regulation of reproduction.Long-term consequences of obesity on female fertility and the health of the offspring.Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms.Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins.Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility.

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Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.

http://www.wikidata.org/entity/Q30430757

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Rescue of obesity-induced infe ...... ckout of the insulin receptor.

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Rescue of obesity-induced infe ...... ckout of the insulin receptor.

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type

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Rescue of obesity-induced infe ...... ckout of the insulin receptor.

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Rescue of obesity-induced infe ...... ckout of the insulin receptor.

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prefLabel

Rescue of obesity-induced infe ...... ckout of the insulin receptor.

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Rescue of obesity-induced infe ...... ckout of the insulin receptor.

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J.CMET.2010.06.010

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Cell Metabolism

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Rescue of obesity-induced infe ...... ckout of the insulin receptor.

@en

P2093

Andrew Wolfe

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Fredric E Wondisford

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Kathryn J Brothers

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Marcus R Messmer

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Ryan S Miller

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Sally Radovick

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Sara A DiVall

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Sheng Wu

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P2860

Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

Neuroendocrine aspects of polycystic ovary syndrome.

The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia.

Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs.

Insulin-like growth factor-I and diabetes. A review.

Distinct and overlapping functions of insulin and IGF-I receptors.

Signalling through IGF-I and insulin receptors: where is the specificity?

Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.

New insights into the integrated physiology of insulin action.

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295-305

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scholarly article

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10.1016/J.CMET.2010.06.010

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3

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12

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2010-09-01T00:00:00Z

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46147458

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20816095

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2935812

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