SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.
about
Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasionAKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophyMetastasis suppressor genes at the interface between the environment and tumor cell growthRe-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitroSuppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.Metastasis suppressors and the tumor microenvironmentMicroenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis.Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulationPrompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury.AKAP12 mediates barrier functions of fibrotic scars during CNS repairDifferential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations.Identification of kinases and regulatory proteins required for cell migration using a transfected cell-microarray system.A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT signal pathway in prostate cancer.Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling.A-kinase anchoring proteins as potential drug targets.EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression.Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia.Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutininKDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.AKAP signaling complexes: pointing towards the next generation of therapeutic targets?Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation.GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer.A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation.The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration.Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma.A transgenic mouse model for early prostate metastasis to lymph nodes.Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12.A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa.Adhesion-mediated cytoskeletal remodeling is controlled by the direct scaffolding of Src from FAK complexes to lipid rafts by SSeCKS/AKAP12.SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts.Deduction of Novel Genes Potentially Involved in Osteoblasts of Rheumatoid Arthritis Using Next-Generation Sequencing and Bioinformatic Approaches.Role of A-Kinase Anchoring Protein Phosphorylation in Alcohol-Induced Liver Injury and Hepatic Stellate Cell Activation.Metastasis suppressors: functional pathways.Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).TGFβ and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.Long noncoding RNA MALAT1 enhances the docetaxel resistance of prostate cancer cells via miR-145-5p-mediated regulation of AKAP12.Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells.
P2860
Q27315878-8FB5B06B-2CA6-410B-8779-18753CB99C4FQ27322014-9D91A18F-DC2E-4EEB-9802-54D0F69715E7Q28394526-98141A83-56DF-45F9-8569-921B85C10136Q34019798-AC9B2BA9-F2D1-48DA-B98D-C2FDFCF58451Q34428538-081CB5AF-3DBE-43D4-B878-59E2F644C9ACQ34648929-EF0E9F8E-D0F1-4E18-8390-671A880F7FBEQ34766640-51F8F603-33A7-43A6-939F-31CFEC028BE6Q34972774-22D9F4BA-C262-4155-91D8-A18420B555FCQ35024133-7A46EF78-20F4-4CDE-BF65-82787C9A78F3Q35142452-C9C4C2EA-6A03-490B-8813-3966E5662AF3Q35156228-BBAC928F-343E-4745-9DE0-581831C95B75Q35166709-44075833-E53B-48D6-8A73-69A32F771BCBQ35194120-B5683079-FC1C-4EB2-B9FE-0A09E1C64A37Q35199286-E7BF0B25-5DA0-444E-A5B0-B09583C7B7D0Q36090763-BAF0694B-82F4-42BC-A30A-36ED876D5050Q36159125-217BBFEE-959D-4123-95FA-521F86C835A6Q36356025-E4C406CD-7B2B-40F2-A7A5-C96565CE0FD7Q36838867-AFF0FC6B-93D2-424E-AAC9-947551722041Q36864524-327A0EF3-F371-47F4-A8EC-AB011CE215D4Q37384068-2EF42E19-8255-4267-A581-36A2DBB702D1Q37427846-3A6221C3-617E-40DE-B03F-B8CB0BC08D99Q37537319-621F8174-815B-44B6-B20B-B354A344922EQ37660331-66F3A765-5818-4416-90D2-4F93023976C3Q37706206-A3DBC287-15B8-4DD4-8E43-9915CA06C465Q38240756-0AFEEFF3-3DB9-41B7-B84E-F007D8A7B889Q38748274-F5A0520B-4898-4A06-9FA2-2A3DE5949D58Q39359295-A4762025-2D7A-4C24-BA24-28A5DC7EE61DQ39448228-7D5EE66E-3DC5-4F5D-8DA3-8F168F932529Q41864582-0611D52C-BDE3-4004-8483-844462095B3CQ41912117-68C9CB2C-5C13-4117-AB12-EED928CDD0F3Q41959192-FFFAFC83-F98A-4B4C-8867-7DEC3B547A92Q42326774-941E5B71-5CCB-4CEF-9DDF-3DB145455911Q42378427-25F61CA4-CF11-4692-AF29-16FA85810415Q47142546-1172D393-944D-4898-9CD9-EF9834744E15Q47228700-E3BEB842-F662-434B-BBF0-CAB5ACC999C8Q47716769-B29D3F7A-174C-435A-8B18-4E061614D6E3Q49474128-96F67EBE-AD5B-4048-AF36-3CB01C3D97E7Q52337636-3C8BB009-76FC-49FF-9629-283F8EDC8D3FQ52597053-90FDFD8B-C90A-4079-86F1-5038492B4798Q52719567-F400471D-8F45-4049-AD90-56210A581E38
P2860
SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@ast
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@en
type
label
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@ast
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@en
prefLabel
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@ast
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@en
P2093
P2860
P356
P1476
SSeCKS/Gravin/AKAP12 inhibits ...... kinase C- Raf/MEK/ERK pathway.
@en
P2093
David Engelberg
Irwin H Gelman
P2860
P304
P356
10.1074/JBC.M109.073494
P407
P577
2009-12-15T00:00:00Z