5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.
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Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C diseaseInhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse.T-type calcium channel blockers as neuroprotective agents.Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neuronsTTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.T-type voltage-gated calcium channels as targets for the development of novel pain therapies.Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid.Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling.Mechanisms of neurosteroid interactions with GABA(A) receptors.Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Neurosteroids, stress and depression: potential therapeutic opportunities.Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca(2+) channels.Pharmacological Inhibition of Voltage-gated Ca(2+) Channels for Chronic Pain Relief.The design and discovery of T-type calcium channel inhibitors for the treatment of central nervous system disorders.Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception.The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment.Neuroactive Steroids: Receptor Interactions and Responses.Neuroactive Steroids: Receptor Interactions and Responses.Neurosteroids in Pain Management: A New Perspective on an Old Player
P2860
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P2860
5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@ast
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@en
type
label
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@ast
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@en
prefLabel
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@ast
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@en
P2093
P356
P1476
5beta-reduced neuroactive ster ...... peripheral analgesics in vivo.
@en
P2093
Barbara C Brimelow
Charles F Zorumski
Douglas F Covey
Kent R Nilsson
Miljen M Jagodic
Seong-Hoon Ko
Slobodan M Todorovic
Sriyani Pathirathna
P304
P356
10.1124/MOL.104.002402
P577
2004-07-27T00:00:00Z