Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
about
Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model.The cybrid model of sporadic Parkinson's disease.Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationshipsParkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundanceReduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy.Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.Stem cell-based models and therapies for neurodegenerative diseasesReduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein.Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection.Bioenergetic origins of complexity and disease.Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson's Disease.Does mitochondrial DNA play a role in Parkinson's disease? A review of cybrid and other supportive evidence.Attention deficit-hyperactivity disorder suffers from mitochondrial dysfunction.Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.The impact of mitochondrial DNA and nuclear genes related to mitochondrial functioning on the risk of Parkinson's disease.Mitochondrial functional alterations in relation to pathophysiology of Huntington's disease.Vulnerability of mesostriatal dopaminergic neurons in Parkinson's diseaseParkinson's syndrome and Parkinson's disease in mitochondrial disorders.Mitochondrial contribution to Parkinson's disease pathogenesis.The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease.Parkinson's disease cybrids, differentiated or undifferentiated, maintain morphological and biochemical phenotypes different from those of control cybrids.Glycolysis-respiration relationships in a neuroblastoma cell line.Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: when mitochondria get nasty.Mitochondrial gene replacement in human pluripotent stem cell-derived neural progenitors.
P2860
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P2860
Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Relationships among molecular ...... s to Parkinson's brain tissues
@ast
Relationships among molecular ...... s to Parkinson's brain tissues
@en
type
label
Relationships among molecular ...... s to Parkinson's brain tissues
@ast
Relationships among molecular ...... s to Parkinson's brain tissues
@en
prefLabel
Relationships among molecular ...... s to Parkinson's brain tissues
@ast
Relationships among molecular ...... s to Parkinson's brain tissues
@en
P2093
P2860
P1476
Relationships among molecular ...... s to Parkinson's brain tissues
@en
P2093
James P Bennett
Jeremy D Rubinstein
K P Mohanakumar
Lisa D Dunham
M Kathleen Borland
Patricia A Trimmer
Paula M Keeney
Roderick Capaldi
P2860
P356
10.1016/J.BBADIS.2008.09.014
P407
P577
2008-10-10T00:00:00Z