Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
about
Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.Dietary chalcones with chemopreventive and chemotherapeutic potential.Design and synthesis of 3,5-disubstituted boron-containing 1,2,4-oxadiazoles as potential combretastatin A-4 (CA-4) analogs.Trans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cellsInhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells.Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3'-O-substituted carbonic ether moiety as potential antitumor agents.Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents.Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatment.Electrostatic potentials and average electron densities of bioisosteres in methylsquarate and acetic acid.Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.Catechol polymers for pH-responsive, targeted drug delivery to cancer cells.Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.Syntheses and cytotoxic properties of the curcumin analogs 2,6-bis(benzylidene)-4-phenylcyclohexanones.Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures.Routes to drug design via bioisosterism of carboxyl and sulfonamide groups.A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor
P2860
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P2860
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@ast
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@en
type
label
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@ast
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@en
prefLabel
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@ast
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@en
P2093
P1476
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
@en
P2093
Ernest Hamel
Jayson Rieger
Jolanta Grembecka
Michael C Edler
Michal Sabat
Milton L Brown
Susan L Mooberry
P304
P356
10.1016/J.CHEMBIOL.2005.06.016
P577
2005-09-01T00:00:00Z