Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP
about
Disruption of the ran system by cysteine oxidation of the nucleotide exchange factor RCC1A pathway linking oxidative stress and the Ran GTPase system in progeria.Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.Nuclear importin α and its physiological importanceTruncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variantSpatial distribution and mobility of the Ran GTPase in live interphase cells.Cellular maintenance of nuclear protein homeostasisTraffic control at the nuclear poreHeat-shock stress activates a novel nuclear import pathway mediated by Hikeshi.
P2860
Q30301217-B6F9F396-E153-434B-9B3D-18D3CA1692D1Q30412267-C168D289-8ABA-42BB-8B83-BD6BCCB7EEAEQ30416354-98550ED3-26AF-4B85-8FC5-CB63F2D8ACA9Q30425591-A63E4648-92D5-4CDE-B409-E070369B064BQ30428604-161FF81A-7D13-4922-A5F4-41ECAC00FD28Q36034989-1EFFC64F-9F10-4395-B0B6-B02DE2A42C76Q36373142-627B60B3-5996-4D3B-8C7C-1B57889FA052Q37392601-9BEAC84E-DB86-4E6F-81F5-2A9E7BE8C189Q38168709-8AD26B57-1C3B-4852-ADB1-F20963C04D1EQ41823112-6D303ECD-2D1E-41F4-AB11-AF580619318FQ42100280-280CC084-74B7-45AE-8B77-3FF1DE9DEC58
P2860
Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Hyperosmotic stress signaling ...... t and the production of RanGTP
@ast
Hyperosmotic stress signaling ...... t and the production of RanGTP
@en
type
label
Hyperosmotic stress signaling ...... t and the production of RanGTP
@ast
Hyperosmotic stress signaling ...... t and the production of RanGTP
@en
prefLabel
Hyperosmotic stress signaling ...... t and the production of RanGTP
@ast
Hyperosmotic stress signaling ...... t and the production of RanGTP
@en
P2860
P356
P1476
Hyperosmotic stress signaling ...... t and the production of RanGTP
@en
P2093
Bryce M Paschal
P2860
P304
P356
10.1091/MBC.E07-01-0089
P577
2007-08-29T00:00:00Z