Regulation of sprouty stability by Mnk1-dependent phosphorylation. - Wikidata - awgldk - TriplyDB

Regulation of sprouty stability by Mnk1-dependent phosphorylation.

Regulation of sprouty stability by Mnk1-dependent phosphorylation.

http://www.wikidata.org/entity/Q30446670

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Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases Mnk kinase pathway: Cellular functions and biological outcomes LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models The VASP-Spred-Sprouty domain puzzle.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.The developing story of Sprouty and cancer.Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses ERK MAP kinase in G cell cycle progression and cancer.A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells.Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.Intermolecular interactions of Sprouty proteins and their implications in development and disease.Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes.Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells.SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition.Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice.Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials.Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation.Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.SPRY2 is phosphorylated by phosphorylated MNK1 Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation.The Role of the p38-MNK-eIF4E Signaling Axis in TNF Production Downstream of the NOD1 Receptor.Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells.

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P2860

Regulation of sprouty stability by Mnk1-dependent phosphorylation.

http://www.wikidata.org/entity/Q30446670

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Regulation of sprouty stability by Mnk1-dependent phosphorylation.

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Regulation of sprouty stability by Mnk1-dependent phosphorylation.

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type

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Regulation of sprouty stability by Mnk1-dependent phosphorylation.

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Regulation of sprouty stability by Mnk1-dependent phosphorylation.

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prefLabel

Regulation of sprouty stability by Mnk1-dependent phosphorylation.

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Regulation of sprouty stability by Mnk1-dependent phosphorylation.

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MCB.26.5.1898-1907.2006

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Molecular and Cellular Biology

P1476

Regulation of sprouty stability by Mnk1-dependent phosphorylation.

@en

P2093

Hong Joo Kim

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John DaSilva

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Lizhong Xu

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W Todd Miller

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P2860

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

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1898-1907

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scholarly article

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10.1128/MCB.26.5.1898-1907.2006

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16479008

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phosphorylation

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1430244

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