A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product.
about
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virusThe protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membraneTransforming gene product of Rous sarcoma virus phosphorylates tyrosineThe sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-srcMonoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin.c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.Evolutionary expression of the neuronal form of the src protein in the brain.Evidence for the common origin of viral and cellular sequences involved in sarcomagenic transformationThe complex of polyoma virus middle-T antigen and pp60c-src.Selected glimpses into the activation and function of Src kinase.Activation of pp60c-src protein kinase activity in human colon carcinoma.Gene-amplification model of carcinogenesis.Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src.Activation of the transforming potential of p60c-src by a single amino acid changeTwo divergent cellular src genes are expressed in Xenopus laevis.Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line.Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebratesTumor promoters alter gene expression and protein phosphorylation in avian cells in culture.DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogasterHomology exists among the transforming sequences of avian and feline sarcoma viruses.pp60c-src in the developing cerebellum.Analysis of the src gene of sarcoma viruses generated by recombination between transformation-defective mutants and quail cellular sequencesTransduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257.In vivo effect of sodium orthovanadate on pp60c-src kinase.Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum.DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.Structural and functional modification of pp60c-src associated with polyoma middle tumor antigen from infected or transformed cells.Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src.Expression of a molecularly cloned human c-src oncogene by using a replication-competent retroviral vectorGeneration of a recombinant Moloney murine leukemia virus carrying the v-src gene of avian sarcoma virus: transformation in vitro and pathogenesis in vivo.A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity.Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma virusesCellular sequences related to three new onc genes of avian sarcoma virus (fps, yes, and ros) and their expression in normal and transformed cells.Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene familyEvidence the pp60src, the product of the Rous sarcoma virus src gene, undergoes autophosphorylation.Increased phosphorylation of vinculin on tyrosine does not occur during the release of stress fibers before mitosis in normal cells.Expression of the chicken c-src gene in COS cellsThe same normal cell protein is phosphorylated after transformation by avian sarcoma viruses with unrelated transforming genes.Markedly elevated levels of an endogenous sarc protein in a hemopoietic precursor cell line.
P2860
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P2860
A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product.
description
1979 nî lūn-bûn
@nan
1979 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1979 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
name
A normal cell protein similar ...... rus transforming gene product.
@ast
A normal cell protein similar ...... rus transforming gene product.
@en
type
label
A normal cell protein similar ...... rus transforming gene product.
@ast
A normal cell protein similar ...... rus transforming gene product.
@en
prefLabel
A normal cell protein similar ...... rus transforming gene product.
@ast
A normal cell protein similar ...... rus transforming gene product.
@en
P2093
P2860
P356
P1476
A normal cell protein similar ...... rus transforming gene product.
@en
P2093
P2860
P304
P356
10.1073/PNAS.76.7.3159
P407
P577
1979-07-01T00:00:00Z