Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue
about
Human HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic DemyelinationAnatomical and Cellular Requirements for the Activation and Migration of Virus-Specific CD8+ T Cells to the Brain during Theiler's Virus InfectionA translatable molecular approach to determining CD8 T-cell epitopes in TMEV infectionTheiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J micePrevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.Predominant clonal accumulation of CD8+ T cells with moderate avidity in the central nervous systems of Theiler's virus-infected C57BL/6 mice.Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virusA CD8 T-cell epitope variant enhances immune targeting to a recombinant picornavirus vaccine antigen.Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells.Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.Capsid-specific cytotoxic T lymphocytes recognize three distinct H-2D(b)-restricted regions of the BeAn strain of Theiler's virus and exhibit different cytokine profilesThe majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelinationDifferences in avidity and epitope recognition of CD8(+) T cells infiltrating the central nervous systems of SJL/J mice infected with BeAn and DA strains of Theiler's murine encephalomyelitis virusPreferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 miceTheiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy.Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosisAn elite controller of picornavirus infection targets an epitope that is resistant to immune escapeGenetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination.Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection.Transition from acute to persistent Theiler's virus infection requires active viral replication that drives proinflammatory cytokine expression and chronic demyelinating disease.Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosisPhylogenetic analysis of the species Theilovirus: emerging murine and human pathogens.
P2860
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P2860
Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@ast
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@en
type
label
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@ast
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@en
prefLabel
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@ast
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@en
P2093
P2860
P1433
P1476
Brain-infiltrating cytolytic T ...... ing a consensus anchor residue
@en
P2093
M A Strausbauch
M Rodriguez
N D Borson
P J Wettstein
W K Nevala
P2860
P304
P577
1997-07-01T00:00:00Z