Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. - Wikidata - awgldk - TriplyDB

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

http://www.wikidata.org/entity/Q30454428

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Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer.Allosteric inhibition of glycogen phosphorylaseaby the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarboxylate Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus.Structure-based predictive models for allosteric hot spots.A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient Current therapies and emerging drugs in the pipeline for type 2 diabetes.Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.In-vivo and in-vitro models of type 2 diabetes in pharmaceutical drug discovery.Efficient synthesis and biological evaluation of epiceanothic acid and related compounds Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins.Glycogen phosphorylase inhibitor N-(3,5-dimethyl-Benzoyl)-N'-(β-D-glucopyranosyl)urea improves glucose tolerance under normoglycemic and diabetic conditions and rearranges hepatic metabolism.Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways.Novel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations.Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase.Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors.Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme.The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors.Pentacyclic triterpenoids from spikes of Prunella vulgaris L. inhibit glycogen phosphorylase and improve insulin sensitivity in 3T3-L1 adipocytes.An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia.Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol.Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes.Regulation of glycogen metabolism in cultured human muscles by the glycogen phosphorylase inhibitor CP-91149.Prolonged inhibition of glycogen phosphorylase in livers of Zucker Diabetic Fatty rats models human glycogen storage diseases.Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations.Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.

P2860

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P2860

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

http://www.wikidata.org/entity/Q30454428

description

1998 nî lūn-bûn

@nan

1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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1998 թվականի փետրվարին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Discovery of a human liver gly ...... lowers blood glucose in vivo.

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Discovery of a human liver gly ...... lowers blood glucose in vivo.

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Discovery of a human liver gly ...... lowers blood glucose in vivo.

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Discovery of a human liver gly ...... lowers blood glucose in vivo.

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Proceedings of the National Academy of Sciences of the United States of America

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Discovery of a human liver gly ...... lowers blood glucose in vivo.

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D E Danley

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D J Hoover

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E J Barrett

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I A Stock

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J L Treadway

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S J Armento

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W H Martin

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P2860

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds

Enzymatic studies of hepatic fragments; application to the classification of glycogenoses

An improved assay for nanomole amounts of inorganic phosphate

Hepatic glucose metabolism and insulin resistance in NIDDM and obesity.

Simultaneous synthesis and degradation of rat liver glycogen. An in vivo nuclear magnetic resonance spectroscopic study

The family of glycogen phosphorylases: structure and function.

An engineered liver glycogen phosphorylase with AMP allosteric activation.

Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.

Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR.

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

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