Altered palmitoylation and neuropathological deficits in mice lacking HIP14. - Wikidata - awgldk - TriplyDB

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

http://www.wikidata.org/entity/Q30462477

about

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease The physiology of protein S-acylation Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14)Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.Fatty acylation of proteins: The long and the short of it.Protein post-translational modifications: In silico prediction tools and molecular modeling.Altered Neuronal Dynamics in the Striatum on the Behavior of Huntingtin Interacting Protein 14 (HIP14) Knockout Mice Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.A systematic analysis of protein palmitoylation in Caenorhabditis elegans Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington disease The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals Combined serial analysis of gene expression and transcription factor binding site prediction identifies novel-candidate-target genes of Nr2e1 in neocortex development.Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers.Ca(2+) handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease.Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.Fat chance! Getting a grip on a slippery modification.Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.Memory and synaptic deficits in Hip14/DHHC17 knockout mice.Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.G-protein signaling, lipid rafts and the possible sites of action for the antidepressant effects of n-3 polyunsaturated fatty acids.Targeting protein palmitoylation: selective inhibitors and implications in disease.Palmitoylation and depalmitoylation defects.SwissPalm: Protein Palmitoylation database.Roles of palmitoylation in axon growth, degeneration and regeneration.Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease.Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models.The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.Palmitoylation and the trafficking of peripheral membrane proteins.Smarter neuronal signaling complexes from existing components: how regulatory modifications were acquired during animal evolution: evolution of palmitoylation-dependent regulation of AMPA-type ionotropic glutamate receptors.Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.Palmitoylation of caspase-6 by HIP14 regulates its activation.

P2860

Q24293871-52F18887-934A-4C0B-AF41-C33EAD5AFB5B Q27014134-0F0B2531-AD67-4B64-856F-53F84CD14C22 Q28119142-CE7838E0-5AA1-46B5-AD7E-F81A6E306D83 Q28537948-5C0F6618-2D93-4970-9AD7-2D880ADF4BBA Q30367884-23A234FD-755F-436F-AF7C-4B5FF63E1D26 Q30388573-4405BDF1-B991-42B4-930B-34B68E44703A Q33580119-979519C9-D52B-4735-A082-4D84023CEEC7 Q33772223-73A58F8E-785F-4FE4-946C-4BB582345470 Q34287351-BC9B036D-210F-4EEA-84B9-6C1952638CDF Q34318514-49E678BC-E141-4D44-BC69-1288B7C5D869 Q34341619-B9EB35A8-37B5-481A-A494-6725C9ADF89D Q34552744-8D3CD737-A797-4926-B8B8-2D36F4D22CEC Q35126285-569321F8-E21D-474E-B624-EA634898E92B Q35146890-7EAF562F-9D4C-4191-A0BD-6DD3CB3D9068 Q35340099-6138FCCD-7258-4FBF-9D55-D4F5C810F213 Q35604442-B7D34169-4444-4FE5-9826-2AE9EEFC17EB Q35708657-294ADC1E-3977-43B1-9520-852F1D0FC149 Q35746623-2623B436-739D-4104-8B1D-791FA2D8D660 Q35893954-8CB89306-37CA-4CE6-B823-E6D61E941659 Q35951187-8D019B2F-8E3D-4804-B196-3725AADD7664 Q36283269-ACF4F1DD-6AAF-4837-B404-E035DA7E5EC7 Q36957153-0EC2A787-5146-4C2B-AECE-3742AC68F016 Q37255018-9E25132C-4EB1-437B-84C7-B7D69AF7D269 Q37395240-52281EF6-D17C-4F99-ADED-F7905A781270 Q37930190-16B8871D-F555-4224-835A-AB3896042165 Q37947984-040F2562-0C9C-4DA1-8349-AB5C64250C42 Q38097891-74E41B5C-7204-4790-B471-B309B793BF5C Q38223437-FC20059B-E2A0-4395-A051-6A3D23299C9D Q38236849-04880E5B-C9EF-4947-B8BF-98953515ECB7 Q38458236-EC0935E3-982E-430B-86E6-F1C3DDBDD6D1 Q39114931-33DB7DA2-64DF-4EB4-B111-7FCC5940F8F4 Q40102175-64E1B948-EB52-41B8-9B8E-1E6E92C57D21 Q40104806-C550DE41-7494-4D23-9B41-3BFD4D16579B Q40159975-4ABE1296-588B-4915-9BD6-29A9787E0D68 Q41849552-016125B7-72EE-40B0-8101-E9D7EF9BDBE2 Q42636157-F014176C-B1B4-4F5C-9B01-31E9C940AD36 Q44406066-3CC296A0-DCE2-4735-BD70-83C9CD1A73FB Q44998217-74B4E4D6-0CEA-413B-A0F5-7DE825143E4E Q45290323-FC839157-D1C3-42E2-95E1-0BEDC5172356 Q45299287-E7898C02-CFE2-49D2-A27C-B55208FFF9A8

P2860

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

http://www.wikidata.org/entity/Q30462477

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

@ast

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

@en

type

label

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

@ast

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

@en

prefLabel

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

@ast

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

@en

P1433

Q30462477-F651354C-6E30-44FB-9272-6E28505065BD

P1476

Q30462477-BB99A63D-F7A1-4A4D-87F0-5071831CFB72

P2093

Q30462477-065CC852-FDB0-4902-B659-70A9D1DE2259

Q30462477-15F5973A-957F-4AA7-89A6-8757E189D4DA

Q30462477-17E99593-20C5-4B09-8B12-E47FC5453197

Q30462477-3A4CD60A-31F6-4120-8BC7-E434FEDB9178

Q30462477-3CE41493-7A9E-4110-9C5B-BA08883A8086

Q30462477-4020E580-3023-4538-96DF-E6DEBDB4C78E

Q30462477-43B02CE5-2C5C-4B35-99BD-CBBC38831B5F

Q30462477-4E013B17-1E6F-4CA8-919A-E5B82FC25F49

Q30462477-4E2AC3A9-AD61-403B-8455-3AA822D0F293

Q30462477-59D9A6E7-9772-4E6C-8F57-D6CB6EDAD020

P2860

Q30462477-0949E767-9C29-47A1-B2CD-7359DF6AA32E

Q30462477-0B62563D-8DA9-4519-8814-47965F250D04

Q30462477-0EF94112-F71E-45DA-98FF-A7878273B9AA

Q30462477-0F68E275-3E1F-4AAA-A46C-1F5F7672CB1B

Q30462477-12B289E7-CF50-49D7-A982-EB53AE56689E

Q30462477-1F82CE55-317A-4E9D-86F7-FDE56B67095C

Q30462477-2320DA4E-9E59-4089-B8D9-7A7E568E3CD2

Q30462477-2687694C-7C87-4965-AC38-0AE94005C5C7

Q30462477-2AD7FBDB-146A-442F-B8EF-41570AB5F8D7

Q30462477-30920397-6FB6-4AD1-80EF-5A7271BE8746

P304

Q30462477-AD0A6922-4F4D-4B44-A410-5641733F2100

P31

Q30462477-67327F41-7FBE-4EAD-9554-7BB28937726E

P356

Q30462477-93B31FE1-D248-4683-B35C-3B7AFEE7C1C3

P433

Q30462477-F32F0B9D-B6EB-4FC6-9E98-86E08908ADF0

P478

Q30462477-721F34B3-07AF-4AB8-94F1-EE434CEBD00E

P50

Q30462477-376BEAE7-A2FF-43E0-8796-0238ECECB6CB

Q30462477-581BE4A5-4637-412C-BB0F-DA048F83365B

Q30462477-8973F50D-868F-48F3-81EC-BA7D67FB2281

Q30462477-EEDD9B2D-DDDC-442E-B27E-7DECEBAEBB98

P577

Q30462477-5E73AF20-F55A-4844-9B12-90F0687347F8

P5875

Q30462477-EE346369-AAD5-4D5D-BB7B-C851993D36AE

P698

Q30462477-BF00EB41-2CEF-4A7E-A996-74F87181FBFD

P932

Q30462477-921D9912-6750-43DD-93C1-F5063CFADCD8

P356

P1433

Human Molecular Genetics

P1476

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

@en

P2093

Austen J Milnerwood

http://www.w3.org/2001/XMLSchema#string

Crystal Doty

http://www.w3.org/2001/XMLSchema#string

Jason P Lerch

http://www.w3.org/2001/XMLSchema#string

Junmei Wan

http://www.w3.org/2001/XMLSchema#string

Kuljeet Vaid

http://www.w3.org/2001/XMLSchema#string

Kun Huang

http://www.w3.org/2001/XMLSchema#string

Nagat Bissada

http://www.w3.org/2001/XMLSchema#string

Nicholas G Davis

http://www.w3.org/2001/XMLSchema#string

R Mark Henkelman

http://www.w3.org/2001/XMLSchema#string

Renaldo C Drisdel

http://www.w3.org/2001/XMLSchema#string

P2860

Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins

Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase

Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

Identification of PSD-95 palmitoylating enzymes

Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

P304

3899-3909

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/HMG/DDR308

http://www.w3.org/2001/XMLSchema#string

P433

20

http://www.w3.org/2001/XMLSchema#string

P478

20

http://www.w3.org/2001/XMLSchema#string

P50

Michael R. Hayden

Roshni Singaraja

P577

2011-07-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51508061

http://www.w3.org/2001/XMLSchema#string

P698

21775500

http://www.w3.org/2001/XMLSchema#string

P932

3177655

http://www.w3.org/2001/XMLSchema#string