Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
about
Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.An integrated view of cisplatin-induced nephrotoxicity and ototoxicityPerilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administrationSodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides.Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs.Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels.Designer aminoglycosides prevent cochlear hair cell loss and hearing lossResolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.A novel chitosan-hydrogel-based nanoparticle delivery system for local inner ear application.Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea.d-Methionine reduces tobramycin-induced ototoxicity without antimicrobial interference in animal models.Gentamicin concentration gradients in scala tympani perilymph following systemic applications.Systemic Delivery and Biodistribution of Cisplatin in Vivo.Finding ways to solve or prevent aminoglycoside-induced ototoxicity?Cochlear pharmacokinetics of cisplatin: an in vivo study in the guinea pig.PharmGKB summary: very important pharmacogene information for MT-RNR1.Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity.Aminoglycoside-Induced Cochleotoxicity: A Review.Mannitol and the blood-labyrinth barrier.Applying U.S. national guidelines for ototoxicity monitoring in adult patients: perspectives on patient populations, service gaps, barriers and solutions.Pharmacogenetics of drug-induced ototoxicity caused by aminoglycosides and cisplatin.Communication pathways to and from the inner ear and their contributions to drug delivery.In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes.Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity.
P2860
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P2860
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@ast
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@en
type
label
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@ast
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@en
prefLabel
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@ast
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@en
P2860
P356
P1433
P1476
Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
@en
P2093
Hongzhe Li
P2860
P2888
P356
10.1038/SREP00159
P407
P577
2011-11-16T00:00:00Z
P5875
P6179
1017048424