Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. - Wikidata - awgldk - TriplyDB

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

http://www.wikidata.org/entity/Q30476563

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Molecular Biology and Clinical Mitigation of Cancer Treatment-Induced Neuropathy Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective The multifaceted role of the renal microvasculature during acute kidney injury Mechanism of Platinum Derivatives Induced Kidney Injury Mechanisms of Cisplatin nephrotoxicity Role of solute carriers in response to anticancer drugs Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.Renal drug transporters and their significance in drug-drug interactions An integrated view of cisplatin-induced nephrotoxicity and ototoxicity Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies.Immunohistochemical localization of OCT2 in the cochlea of various species.Sensory hair cell death and regeneration in fishes The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin.Membrane transporters as mediators of Cisplatin effects and side effects.Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.The design and screening of drugs to prevent acquired sensorineural hearing loss Role of the copper transporter, CTR1, in platinum-induced ototoxicity.Clerosterol from vinegar-baked radix bupleuri modifies drug transport.Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Pathophysiology of cisplatin-induced acute kidney injury.In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem.Ototoxic Model of Oxaliplatin and Protection from Nicotinamide Adenine Dinucleotide Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS.Gender difference in Cisplatin-induced nephrotoxicity in a rat model.Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions Pharmacogenomics of cisplatin-induced ototoxicity EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer Cisplatin ototoxicity in rat cochlear organotypic cultures.Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea.Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin.Contribution of tumoral and host solute carriers to clinical drug response.Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio).Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury

P2860

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P2860

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

http://www.wikidata.org/entity/Q30476563

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Organic cation transporter 2 m ...... for protective interventions.

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Organic cation transporter 2 m ...... for protective interventions.

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AJPATH.2010.090610

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The American Journal of Pathology

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Organic cation transporter 2 m ...... for protective interventions.

@en

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Alfred H Schinkel

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Bayram Edemir

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Hermann Koepsell

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Michael Holtkamp

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P2860

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

The SLC22 drug transporter family

NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo

Cellular processing of platinum anticancer drugs

A new method for imaging and 3D reconstruction of mammalian cochlea by fluorescent confocal microscopy.

Repeat administration of drugs as a means to assess the genetic component in pharmacological variability.

Gene expression levels and immunolocalization of organic ion transporters in the human kidney.

Organic cation transporters.

Molecular mechanisms of resistance and toxicity associated with platinating agents.

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1169-1180

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scholarly article

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10.2353/AJPATH.2010.090610

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3

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176

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Heribert Jürgens

Antoinette am Zehnhoff-Dinnesen

Claudia Lanvers-Kaminsky

Giuliano Ciarimboli

Eberhard Schlatter

Hermann Pavenstädt

Michael Sperling

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2010-01-28T00:00:00Z

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41173717

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20110413

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2832140

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