Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
about
Critical role of gap junction coupled KATP channel activity for regulated insulin secretionPhase transitions in the multi-cellular regulatory behavior of pancreatic islet excitabilityChronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cellsThe MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouseMembrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management.Modeling K,ATP--dependent excitability in pancreatic islets.Hyperinsulinism in infancy: from basic science to clinical disease.Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in miceLow Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ.Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion.Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice.Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvaeExpression and function of ATP-dependent potassium channels in zebrafish islet β-cells.Use of mouse models in studying type 2 diabetes mellitus.The diabetic β-cell: hyperstimulated vs. hyperexcited.Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans.All mixed up: defining roles for β-cell subtypes in mature islets.Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitusTargeted expression of Kir6.2 in mitochondria confers protection against hypoxic stress.Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamicsGap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet.Control of Kir channel gating by cytoplasmic domain interface interactionsA mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse.Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats.beta-cell hyperexcitability: from hyperinsulinism to diabetes.Impaired glucose-stimulated insulin secretion and reduced β-cell mass in pancreatic islets of hyperthyroid rats.Gap-junction coupling and ATP-sensitive potassium channels in human β-cell clusters: Effects on emergent dynamics.The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady.The possible mechanisms by which maternal hypothyroidism impairs insulin secretion in adult male offspring in rats.Mouse Models of β-cell KATP Channel Dysfunction.
P2860
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P2860
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@ast
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@en
type
label
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@ast
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@en
prefLabel
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@ast
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@en
P2093
P2860
P356
P1476
Hyperinsulinism induced by targeted suppression of beta cell KATP channels.
@en
P2093
B A Marshall
C G Nichols
J C Koster
J D Johnson
K P Markova
M S Remedi
P2860
P304
16992-16997
P356
10.1073/PNAS.012479199
P407
P577
2002-12-16T00:00:00Z