How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation.
about
Mechanical regulation of T-cell functionsMolecular dynamics simulations of forced unbending of integrin α(v)β₃Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesCrystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragmentComplete integrin headpiece opening in eight stepsHeading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical EnvironmentsLymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forcesIntegrins and extracellular matrix in mechanotransductionFocal adhesions are sites of integrin extension.Forcing switch from short- to intermediate- and long-lived states of the alphaA domain generates LFA-1/ICAM-1 catch bondsLateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesionStructurally governed cell mechanotransduction through multiscale modeling.T cell receptor triggering by force.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Recreation of the terminal events in physiological integrin activation.Acidic extracellular pH promotes activation of integrin α(v)β(3).Neutrophil adhesion and chemotaxis depend on substrate mechanics.Role of altered sialylation of the I-like domain of beta1 integrin in the binding of fibronectin to beta1 integrin: thermodynamics and conformational analysesConformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1The final steps of integrin activation: the end gameRegulation of catch binding by allosteric transitions.Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force.A single disulfide bond disruption in the β3 integrin subunit promotes thiol/disulfide exchange, a molecular dynamics study.Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling.The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular DesignStructure and mechanics of integrin-based cell adhesion.Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.Demonstration of catch bonds between an integrin and its ligand.Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread?Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling.Regulation of integrin activity and signallingLinking integrin conformation to function.A model for cyclic mechanical reinforcement.Protein Mechanics: A New Frontier in Biomechanics.Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways.Integrin activation dynamics between the RGD-binding site and the headpiece hinge.Rolling cell adhesionThe heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions.Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.
P2860
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P2860
How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
How the headpiece hinge angle ...... namics of integrin activation.
@ast
How the headpiece hinge angle ...... namics of integrin activation.
@en
type
label
How the headpiece hinge angle ...... namics of integrin activation.
@ast
How the headpiece hinge angle ...... namics of integrin activation.
@en
prefLabel
How the headpiece hinge angle ...... namics of integrin activation.
@ast
How the headpiece hinge angle ...... namics of integrin activation.
@en
P2860
P356
P1476
How the headpiece hinge angle ...... namics of integrin activation.
@en
P2093
Eileen Puklin-Faucher
P2860
P304
P356
10.1083/JCB.200602071
P407
P577
2006-10-01T00:00:00Z