Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles.
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Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.Insulin regulates Glut4 confinement in plasma membrane clusters in adipose cellsSites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubulesAS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membraneInsulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesiclesGLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistanceInhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation.Identification of a distal GLUT4 trafficking event controlled by actin polymerizationIdentification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging.A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes.Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis.Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficMice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.Spatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by the cytoskeleton in endocrine cells.Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes.Dual-mode of insulin action controls GLUT4 vesicle exocytosis.Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data.GLUT4 exocytosis.Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytesInsulin controls the spatial distribution of GLUT4 on the cell surface through regulation of its postfusion dispersal.Rab10 delivers GLUT4 storage vesicles to the plasma membrane.Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissuesInsulin triggers surface-directed trafficking of sequestered GLUT4 storage vesicles marked by Rab10.Biogenesis and regulation of insulin-responsive vesicles containing GLUT4.Mapping insulin/GLUT4 circuitry.A proteolytic pathway that controls glucose uptake in fat and muscle.Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking.Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation.Molecular mechanisms controlling GLUT4 intracellular retention.A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytesRUVBL2, a novel AS160-binding protein, regulates insulin-stimulated GLUT4 translocation.Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response.Characterization of GLUT4-containing vesicles in 3T3-L1 adipocytes by total internal reflection fluorescence microscopy.Total Internal Reflection Fluorescence Microscopy to Study GLUT4 Trafficking.
P2860
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P2860
Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@ast
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@en
type
label
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@ast
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@en
prefLabel
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@ast
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@en
P2093
P2860
P356
P1476
Direct quantification of fusio ...... ion of GLUT4 storage vesicles.
@en
P2093
Junmei Fan
Liangyi Chen
P2860
P304
P356
10.1074/JBC.M708688200
P407
P577
2007-12-06T00:00:00Z