Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.
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Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophyTowards the Physics of Calcium Signalling in PlantsThe cellular and molecular basis of bitter tastant-induced bronchodilationCalcium signals driven by single channel noiseDynamic visualization of calcium-dependent signaling in cellular microdomainsBidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organellesDifferential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptorMean field strategies induce unrealistic non-linearities in calcium puffsSubplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretionRecording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp.Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.A stochastic model of calcium puffs based on single-channel data.A comparison of fluorescent Ca²⁺ indicators for imaging local Ca²⁺ signals in cultured cells.Intra-cluster percolation of calcium signalsQuantifying calcium fluxes underlying calcium puffs in Xenopus laevis oocytes.Frequency and relative prevalence of calcium blips and puffs in a model of small IP₃R clusters.Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action.Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readoutModulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals.Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributionsTermination of calcium puffs and coupled closings of inositol trisphosphate receptor channels.An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imagingCooperative and stochastic calcium releases from multiple calcium puff sites generate calcium microdomains in intact Hela cells.Multi-scale data-driven modeling and observation of calcium puffs.Termination of Ca²+ release for clustered IP₃R channels.Unitary Ca(2+) current through recombinant type 3 InsP(3) receptor channels under physiological ionic conditions.Derivation of Ca2+ signals from puff properties reveals that pathway function is robust against cell variability but sensitive for controlHierarchic stochastic modelling applied to intracellular Ca(2+) signalsCalcium oscillations.Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs.Fluorescence fluctuations and equivalence classes of Ca²⁺ imaging experiments.A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells.Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomesImaging local Ca2+ signals in cultured mammalian cells.Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathologyModulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model.Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.Endogenous cytosolic Ca(2+) buffering is necessary for TRPM4 activity in cerebral artery smooth muscle cells.Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular levelThe probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster.
P2860
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P2860
Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@ast
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@en
type
label
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@ast
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@en
prefLabel
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@ast
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@en
P2860
P356
P1476
Imaging the quantal substructu ...... ffs in intact mammalian cells.
@en
P2093
Ian F Smith
Ian Parker
P2860
P304
P356
10.1073/PNAS.0810799106
P407
P577
2009-03-30T00:00:00Z