A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. - Wikidata - awgldk - TriplyDB

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.

http://www.wikidata.org/entity/Q30488360

about

Recent developments in using mechanistic cardiac modelling for drug safety evaluation Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules.Continuum molecular simulation of large conformational changes during ion-channel gating Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue Graphical approach to model reduction for nonlinear biochemical networks.Towards structural systems pharmacology to study complex diseases and personalized medicine Genetic variants in Alzheimer disease - molecular and brain network approaches Conformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1.Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.Targeting intracellular calcium cycling in catecholaminergic polymorphic ventricular tachycardia: a theoretical investigation.Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI).KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps Computational modeling of subcellular transport and signaling.Patterning methods for polymers in cell and tissue engineering APBSmem: a graphical interface for electrostatic calculations at the membrane.State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation Multi-scale electrophysiology modeling: from atom to organ Mathematical modeling of physiological systems: an essential tool for discovery.Three-residue loop closure in proteins: a new kinematic method reveals a locus of connected loop conformations.Ion channel associated diseases: overview of molecular mechanisms KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.Free-energy landscape of ion-channel voltage-sensor-domain activation Integrative modeling of the cardiac ventricular myocyte.Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis.Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter.The virtual heart as a platform for screening drug cardiotoxicity.Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Equilibrium fluctuation relations for voltage coupling in membrane proteins.Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1 Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2 Calcium dynamics and signaling in vascular regulation: computational models.Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1 R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation.Computational tools to investigate genetic cardiac channelopathies.In silico assessment of drug safety in human heart applied to late sodium current blockers At the heart of computational modelling.The KCNE Tango - How KCNE1 Interacts with Kv7.1.

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P2860

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.

http://www.wikidata.org/entity/Q30488360

description

2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

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name

A multiscale model linking ion ...... the cardiac action potential.

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A multiscale model linking ion ...... the cardiac action potential.

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type

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A multiscale model linking ion ...... the cardiac action potential.

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A multiscale model linking ion ...... the cardiac action potential.

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Proceedings of the National Academy of Sciences of the United States of America

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A multiscale model linking ion ...... the cardiac action potential.

@en

P2093

Ali Nekouzadeh

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Dick Wu

http://www.w3.org/2001/XMLSchema#string

Hua Pan

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Jianmin Cui

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Keith F Decker

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Yoram Rudy

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P2860

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

Electrostatics of nanosystems: application to microtubules and the ribosome

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

VMD: visual molecular dynamics

Scalable molecular dynamics with NAMD

Comparative protein modelling by satisfaction of spatial restraints

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

A quantitative assessment of models for voltage-dependent gating of ion channels.

Kramers' diffusion theory applied to gating kinetics of voltage-dependent ion channels.

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11102-11106

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27

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106

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Jonathan R. Silva

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2009-06-22T00:00:00Z

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26314307

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19549851

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molecular dynamics simulation

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2700153

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