The structure of the myosin VI motor reveals the mechanism of directionality reversal
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How are the cellular functions of myosin VI regulated within the cell?Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in DiseasePoorly understood aspects of striated muscle contractionDense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filamentsCalcium can mobilize and activate myosin-VIAllosteric communication in myosin V: from small conformational changes to large directed movementsThe post-rigor structure of myosin VI and implications for the recovery strokeMyosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its ReachCalmodulin Wraps around Its Binding Domain in the Plasma Membrane Ca2+ Pump Anchored by a Novel 18-1 MotifInsights into the Importance of Hydrogen Bonding in the γ-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Serine 236,Role of Insert-1 of Myosin VI in Modulating Nucleotide AffinityStructure of androcam supports specialized interactions with myosin VIProcessive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VIA vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning.Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channelStrain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor ActivityMouse myosin-19 is a plus-end-directed, high-duty ratio molecular motorAdaptive evolution of the myo6 gene in old world fruit bats (family: pteropodidae)Lever-arm mechanics of processive myosinsFunctional characterization of the N-terminal region of myosin-2.Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains.Biochemical and bioinformatic analysis of the myosin-XIX motor domain.Optical traps to study properties of molecular motors.The power stroke of myosin VI and the basis of reverse directionality.Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm.Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments.Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transportPlus-end directed myosins accelerate actin filament sliding by single-headed myosin VI.Structure of actomyosin rigour complex at 5.2 Å resolution and insights into the ATPase cycle mechanismFunctional studies of individual myosin molecules.A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cellsMyosin individualized: single nucleotide polymorphisms in energy transduction.Mechanical coupling in myosin V: a simulation studyExome sequencing identifies a novel mutation in the MYH6 gene in a family with early-onset sinus node dysfunction, ventricular arrhythmias, and cardiac arrestMyosin isoform determines the conformational dynamics and cooperativity of actin filaments in the strongly bound actomyosin complex.A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd.Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scatteringMyosin VI: an innovative motor that challenged the swinging lever arm hypothesisContribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing.Structure of the light chain-binding domain of myosin V
P2860
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P2860
The structure of the myosin VI motor reveals the mechanism of directionality reversal
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
name
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@ast
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@en
type
label
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@ast
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@en
prefLabel
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@ast
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@en
P2093
P2860
P356
P1433
P1476
The structure of the myosin VI motor reveals the mechanism of directionality reversal
@en
P2093
Amber L Wells
Anne Houdusse
Carl A Morris
Christopher M Yengo
H Lee Sweeney
Julie Ménétrey
P2860
P2888
P304
P356
10.1038/NATURE03592
P407
P50
P577
2005-06-01T00:00:00Z
P5875
P6179
1031293875